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Literature summary extracted from

  • Krishnaswamy, S.; Hao, Q.; Von Moltke, L.L.; Greenblatt, D.J.; Court, M.H.
    Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6 (2004), Drug Metab. Dispos., 32, 862-869.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 expression of diverse isozymes in a lymphoblast expression system, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 5-hydroxytryptophol competitive inhibition of serotonin glucuronidation Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 0.135
-
 5-hydroxytryptophol isozyme UGT1A6, pH 7.5, 37°C Homo sapiens
2.4.1.17 3.674
-
 5-hydroxytryptophol isozyme UGT1A9, pH 7.5, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens P19224 isozyme UGT1A6; isozymes UGT1A6 and UGT1A9
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.17 additional information
-
 activity of diverse recombinant isozymes with the different substrates Homo sapiens
2.4.1.17 0.0016
-
 liver microsomes, substrate morphine 3-glucuronide Homo sapiens
2.4.1.17 0.0044
-
 liver microsomes, substrate serotonin Homo sapiens
2.4.1.17 0.0052
-
 liver microsomes, substrate N-acetylserotonin Homo sapiens
2.4.1.17 0.0072
-
 liver microsomes, substrate 6-hydroxymelatonin Homo sapiens
2.4.1.17 0.008 4 liver microsomes, substrate 5-hydroxytryptophol Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 UDP-glucuronate + 5-hydroxytryptophol isozymes UGT1A6 and UGT1A9, the latter shows over 20fold lower activity Homo sapiens UDP + 5-hydroxytryptophol beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + 6-hydroxymelatonin
-
 Homo sapiens UDP + 6-hydroxymelatonin beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + morphine 3-glucuronide
-
 Homo sapiens UDP + ?
-
 ?
2.4.1.17 UDP-glucuronate + N-acetylserotonin
-
 Homo sapiens UDP + N-acetylserotonin beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + serotonin
-
 Homo sapiens UDP + serotonin beta-D-glucuronide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase 1A6
-
 Homo sapiens
2.4.1.17 UGT1A6
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.5
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.17 0.2
-
 5-hydroxytryptophol isozyme UGT1A6, pH 7.5, 37°C Homo sapiens
2.4.1.17 0.29
-
 5-hydroxytryptophol liver microsomes, pH 7.5, 37°C Homo sapiens