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Literature summary extracted from

  • Watanabe, Y.; Nakajima, M.; Ohashi, N.; Kume, T.; Yokoi, T.
    Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDP-glucuronosyltransferase 1A1 (2003), Drug Metab. Dispos., 31, 589-595.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 4-nitrophenol inhibits the etoposide glucuronosyltransferase activity in liver microsomes Homo sapiens
2.4.1.17 beta-estradiol completely inhibits the etoposide glucuronosyltransferase activity in liver microsomes at 0.5 mM Homo sapiens
2.4.1.17 bilirubin completely inhibits the etoposide glucuronosyltransferase activity in liver microsomes at 0.5 mM Homo sapiens
2.4.1.17 imipramine inhibits the etoposide glucuronosyltransferase activity in liver microsomes Homo sapiens
2.4.1.17 morphine inhibits the etoposide glucuronosyltransferase activity in liver microsomes Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 0.44
-
 etoposide liver microsomes, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.5
-
 etoposide recombinant isozyme UGT1A1, pH 7.4, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens P22309
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.17 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 UDP-glucuronate + etoposide isozyme UGT1A1 is specific for etoposide Homo sapiens UDP + etoposide beta-D-glucuronide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UDP-glucuronosyltransferase 1A1
-
 Homo sapiens
2.4.1.17 UGT
-
 Homo sapiens
2.4.1.17 UGT1A1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.4
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.17 additional information
-
 additional information
-
 Homo sapiens