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Literature summary extracted from

  • Lu, H.; Meng, X.; Yang, C.S.
    Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (-)-epigallocatechin gallate (2003), Drug Metab. Dispos., 31, 572-579.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.6 (-)-epigallocatechin gallate potent inhibitor with epigallocatechin or 3,4-dihydroxy-L-Phe as substrates Sus scrofa
2.1.1.6 (-)-epigallocatechin gallate-4''-O-glucuronide with epigallocatechin or 3,4-dihydroxy-L-Phe as substrates Sus scrofa
2.1.1.6 (-)-epigallocatechin gallate-7-O-glucuronide with epigallocatechin or 3,4-dihydroxy-L-Phe as substrates Sus scrofa
2.1.1.6 (-)epicatechin gallate3,5-dinitrocatechol with epigallocatechin or 3,4-dihydroxy-L-Phe as substrates Sus scrofa
2.1.1.6 4''-O-methyl epigallocatechin gallate potent inhibitor with epigallocatechin or 3,4-dihydroxy-L-Phe as substrates Sus scrofa
2.1.1.6 4',3'',4''-tri-O-methyl epigallocatechin gallate substrate: epigallocatechin Sus scrofa
2.1.1.6 4',4''-di-O-methyl epigallocatechin gallate potent inhibitor with epigallocatechin or 3,4-dihydroxy-L-Phe as substrates Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.6 0.00017
-
 epigallocatechin gallate
-
 Sus scrofa
2.1.1.6 0.004
-
 epigallocatechin gallate
-
 Homo sapiens
2.1.1.6 0.0048
-
 epigallocatechin gallate
-
 Rattus norvegicus
2.1.1.6 0.0081
-
 epigallocatechin
-
 Sus scrofa
2.1.1.6 0.0117
-
 epigallocatechin
-
 Homo sapiens
2.1.1.6 0.0117
-
 epigallocatechin
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.6 cytosol
-
 Homo sapiens 5829
-
2.1.1.6 cytosol
-
 Rattus norvegicus 5829
-
2.1.1.6 cytosol
-
 Sus scrofa 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Homo sapiens
-
-
-
2.1.1.6 Rattus norvegicus
-
-
-
2.1.1.6 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.6 liver
-
 Homo sapiens
-
2.1.1.6 liver
-
 Rattus norvegicus
-
2.1.1.6 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.6 S-adenosyl-L-homocysteine + 4''-O-methyl epigallocatechin gallate
-
 Homo sapiens S-adenosyl-L-homocysteine + 4',4''-di-O-methyl epigallocatechin gallate
-
 ?
2.1.1.6 S-adenosyl-L-homocysteine + 4''-O-methyl epigallocatechin gallate
-
 Rattus norvegicus S-adenosyl-L-homocysteine + 4',4''-di-O-methyl epigallocatechin gallate
-
 ?
2.1.1.6 S-adenosyl-L-homocysteine + 4''-O-methyl epigallocatechin gallate
-
 Sus scrofa S-adenosyl-L-homocysteine + 4',4''-di-O-methyl epigallocatechin gallate
-
 ?
2.1.1.6 S-adenosyl-L-methionine + 3,4-dihydroxy-L-Phe
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + 3,4-dihydroxy-L-Phe
-
 Rattus norvegicus S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + 3,4-dihydroxy-L-Phe
-
 Sus scrofa S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + epigallocatechin
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + epigallocatechin
-
 Rattus norvegicus S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + epigallocatechin
-
 Sus scrofa S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + epigallocatechin gallate
-
 Homo sapiens S-adenosyl-L-homocysteine + 4''-O-methyl epigallocatechin gallate
-
 ?
2.1.1.6 S-adenosyl-L-methionine + epigallocatechin gallate
-
 Rattus norvegicus S-adenosyl-L-homocysteine + 4''-O-methyl epigallocatechin gallate
-
 ?
2.1.1.6 S-adenosyl-L-methionine + epigallocatechin gallate
-
 Sus scrofa S-adenosyl-L-homocysteine + 4''-O-methyl epigallocatechin gallate
-
 ?
2.1.1.6 S-adenosyl-L-methionine + L-Dopa
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + L-Dopa
-
 Rattus norvegicus S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + L-Dopa
-
 Sus scrofa S-adenosyl-L-homocysteine + ?
-
 ?