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Literature summary extracted from

  • Di Sano, F.; Fazi, B.; Citro, G.; Lovat, P.E.; Cesareni, G.; Piacentini, M.
    Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells (2003), Cancer Res., 63, 3860-3865.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.80 expression of enzyme gene in antisense orientation, two-hybrid system: coexpression with the reticulon RTN family, interaction especially with RTN-1C Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.80 additional information antisense expression inhibits enzyme activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.80 (D-threo)-1-phenyl-2-decanoylamino-3-morpholino-1-propanol specific inhibitor Homo sapiens
2.4.1.80 additional information enzyme inhibition by antisense expression Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.80 additional information Homo sapiens enzyme decreases apoptosis and induces multidrug resistance, functional interaction with RTN-1C modulates enzyme activity and regulates chemotherapeutic-induced apoptosis in neuroepithelioma cells ?
-
 ?
2.4.1.80 UDP-glucose + N-acylsphingosine Homo sapiens key step in biosynthesis of glycosphingolipids UDP + D-glucosyl-N-acylsphingosine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.80 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.80 neuroepithelioma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.80 additional information enzyme decreases apoptosis and induces multidrug resistance, functional interaction with RTN-1C modulates enzyme activity and regulates chemotherapeutic-induced apoptosis in neuroepithelioma cells Homo sapiens ?
-
 ?
2.4.1.80 UDP-glucose + N-acylsphingosine
-
 Homo sapiens UDP + D-glucosyl-N-acylsphingosine
-
 ?
2.4.1.80 UDP-glucose + N-acylsphingosine key step in biosynthesis of glycosphingolipids Homo sapiens UDP + D-glucosyl-N-acylsphingosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.80 GCS
-
 Homo sapiens
2.4.1.80 glucosylceramide synthase
-
 Homo sapiens