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Literature summary extracted from
- Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase (2003), BMC Biochem., 4, 13.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.7.1.3 | synthesis | of inhibitors of kynureninase could prove to be useful in the development of the successful treatment regimen for neurological disorders such as septicemia, AIDS related dementia, Lyme disease, Huntington's and Alzheimer's disease | Homo sapiens |
| 3.7.1.3 | synthesis | of inhibitors of kynureninase could prove to be useful in the development of the successful treatment regimen for neurological disorders such as septicemia, AIDS related dementia, Lyme disease, Huntington's and Alzheimer's disease | Rattus norvegicus |
| 3.7.1.3 | synthesis | of inhibitors of kynureninase could prove to be useful in the development of the successful treatment regimen for neurological disorders such as septicemia, AIDS related dementia, Lyme disease, Huntington's and Alzheimer's disease | Pseudomonas fluorescens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.7.1.3 | overexpression is achieved with the Bac-to-Bac baculovirus expression system | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.7.1.3 | 3,5-dihydroxydeaminokynurenine | - |
Homo sapiens |  |
| 3.7.1.3 | 3-hydroxydeaminokynurenine | competitive and non competitive inhibition | Homo sapiens | |
| 3.7.1.3 | 3-hydroxydeaminokynurenine | competitive and non competitive inhibition | Pseudomonas fluorescens | |
| 3.7.1.3 | 3-hydroxydeaminokynurenine | competitive and non competitive inhibition | Rattus norvegicus | |
| 3.7.1.3 | 3-methoxydeaminokynurenine | competitive and non competitive inhibition | Homo sapiens | |
| 3.7.1.3 | 3-methoxydeaminokynurenine | competitive and non competitive inhibition | Pseudomonas fluorescens | |
| 3.7.1.3 | 3-methoxydeaminokynurenine | competitive and non competitive inhibition | Rattus norvegicus | |
| 3.7.1.3 | D-kynurenine | - |
Homo sapiens | |
| 3.7.1.3 | deaminokynurenine | competitive and non competitive inhibition | Pseudomonas fluorescens | |
| 3.7.1.3 | L-kynurenine | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.7.1.3 | 0.003 | - |
3-hydroxy-L-kynurenine | - |
Homo sapiens | |
| 3.7.1.3 | 0.005 | - |
3-hydroxy-L-kynurenine | - |
Rattus norvegicus | |
| 3.7.1.3 | 0.0442 | - |
L-kynurenine | - |
Pseudomonas fluorescens | |
| 3.7.1.3 | 0.2 | - |
3-hydroxy-L-kynurenine | - |
Pseudomonas fluorescens | |
| 3.7.1.3 | 0.5 | - |
L-kynurenine | - |
Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.7.1.3 | 52400 | - |
recombinant enzyme, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.7.1.3 | 3-hydroxy-L-kynurenine + H2O | Homo sapiens | - |
3-hydroxyanthranilate + L-alanine | - |
? | |
| 3.7.1.3 | 3-hydroxy-L-kynurenine + H2O | Rattus norvegicus | - |
3-hydroxyanthranilate + L-alanine | - |
? | |
| 3.7.1.3 | 3-hydroxy-L-kynurenine + H2O | Pseudomonas fluorescens | - |
3-hydroxyanthranilate + L-alanine | - |
? | |
| 3.7.1.3 | L-kynurenine + H2O | Rattus norvegicus | L-tryptophan metabolism | anthranilate + L-alanine | - |
? | |
| 3.7.1.3 | L-kynurenine + H2O | Pseudomonas fluorescens | L-tryptophan metabolism | anthranilate + L-alanine | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.7.1.3 | Homo sapiens | - |
- |
- |
| 3.7.1.3 | Pseudomonas fluorescens | - |
- |
- |
| 3.7.1.3 | Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.7.1.3 | no modification | - |
Homo sapiens |
| 3.7.1.3 | no modification | - |
Rattus norvegicus |
| 3.7.1.3 | no modification | - |
Pseudomonas fluorescens |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.7.1.3 | - |
Rattus norvegicus |
| 3.7.1.3 | - |
Pseudomonas fluorescens |
| 3.7.1.3 | by strong cationic column, strong anion exchange column and hydroxyapatite column | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.7.1.3 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.7.1.3 | 0.3 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.7.1.3 | 3-hydroxy-L-kynurenine + H2O | - |
Homo sapiens | 3-hydroxyanthranilate + L-alanine | - |
? | |
| 3.7.1.3 | 3-hydroxy-L-kynurenine + H2O | - |
Rattus norvegicus | 3-hydroxyanthranilate + L-alanine | - |
? | |
| 3.7.1.3 | 3-hydroxy-L-kynurenine + H2O | - |
Pseudomonas fluorescens | 3-hydroxyanthranilate + L-alanine | - |
? | |
| 3.7.1.3 | 3-hydroxy-L-kynurenine + H2O | the hydroxyl group at the 3-position thus appears to be an important recognition element | Homo sapiens | 3-hydroxyanthranilate + L-alanine | - |
? | |
| 3.7.1.3 | L-kynurenine + H2O | - |
Rattus norvegicus | anthranilate + L-alanine | - |
? | |
| 3.7.1.3 | L-kynurenine + H2O | - |
Pseudomonas fluorescens | anthranilate + L-alanine | - |
? | |
| 3.7.1.3 | L-kynurenine + H2O | L-tryptophan metabolism | Rattus norvegicus | anthranilate + L-alanine | - |
? | |
| 3.7.1.3 | L-kynurenine + H2O | L-tryptophan metabolism | Pseudomonas fluorescens | anthranilate + L-alanine | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.7.1.3 | pyridoxal 5'-phosphate | - |
Homo sapiens | |
| 3.7.1.3 | pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
| 3.7.1.3 | pyridoxal 5'-phosphate | - |
Pseudomonas fluorescens | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.7.1.3 | 0.000005 | - |
3-hydroxydeaminokynurenine | - |
Homo sapiens | |
| 3.7.1.3 | 0.00004 | - |
3-hydroxydeaminokynurenine | - |
Rattus norvegicus | |
| 3.7.1.3 | 0.0001 | - |
3-hydroxydeaminokynurenine | - |
Pseudomonas fluorescens | |
| 3.7.1.3 | 0.00025 | - |
3,5-dihydroxydeaminokynurenine | - |
Homo sapiens | |
| 3.7.1.3 | 0.01 | - |
3-methoxydeaminokynurenine | - |
Pseudomonas fluorescens | |
| 3.7.1.3 | 0.012 | - |
D-kynurenine | - |
Homo sapiens | |
| 3.7.1.3 | 0.012 | - |
deaminokynurenine | - |
Pseudomonas fluorescens | |
| 3.7.1.3 | 0.015 | - |
3-methoxydeaminokynurenine | - |
Homo sapiens | |
| 3.7.1.3 | 0.02 | - |
L-kynurenine | - |
Homo sapiens | |
| 3.7.1.3 | 0.175 | - |
2-amino-4-(3-methoxyphenyl)-4-oxobutanoic acid | - |
Rattus norvegicus | |
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