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Literature summary extracted from
- Trypanothione reductase from the human parasite Entamoeba histolytica: a new drug target (2005), Biotechnol. Appl. Biochem., 41, 105-115.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.8.1.12 | pharmacology | enzyme is a drug target | Entamoeba histolytica |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.8.1.12 | gene EHTR, DNA and amino acid sequence determination and analysis, phylogenetic analysis | Entamoeba histolytica |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.12 | trypanothione disulfide + NADPH | Entamoeba histolytica | - |
trypanothione + NADP+ | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.12 | Entamoeba histolytica | Q8MZR8 | putative, fragment; human parasite, strain HK9 | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.8.1.12 | trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | reducing catalytic site CVNVGC | Entamoeba histolytica |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.1.12 | trophozoite | - |
Entamoeba histolytica | - |
| 1.8.1.12 | trypanosomoid form | - |
Entamoeba histolytica | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.12 | trypanothione disulfide + NADPH | - |
Entamoeba histolytica | trypanothione + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.12 | TR | - |
Entamoeba histolytica |
| 1.8.1.12 | trypanothione reductase | - |
Entamoeba histolytica |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.12 | 25 | - |
assay at | Entamoeba histolytica |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.12 | 7.5 | - |
assay at | Entamoeba histolytica |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.12 | FAD | 2 molecules per enzyme dimer | Entamoeba histolytica | |
| 1.8.1.12 | NADPH | dependent on | Entamoeba histolytica | |
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Release 2023.1 (January 2023)
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