EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.2.3 | medicine | potential target for antineoplastic chemotherapy | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.2.3 | Cappsin 1 | non-competitive, inhibition of activity by preventing the formation of dimers | Homo sapiens | |
2.1.2.3 | Cappsin 2 | some derivatives of Cappepsin are also inhibitory, inhibition of activity by preventing the formation of dimers | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | Homo sapiens | penultimate step of the purine de novo synthesis pathway | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.2.3 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | - |
Homo sapiens | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? | |
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | penultimate step of the purine de novo synthesis pathway | Homo sapiens | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.2.3 | dimer | transformylase activity is formed upon dimerization of the enzyme | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.2.3 | AICAR transformylase/inosine monophosphate cyclohydrolase | bifunctional enzyme catalyzing the last two steps of the purine de novo synthesis pathway | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.2.3 | 0.003 | - |
Cappsin 1 | - |
Homo sapiens |