Literature summary extracted from

Lukyanenko, Y.; Chen, J.J.; Hutson, J.C.
Testosterone regulates 25-hydroxycholesterol production in testicular macrophages (2002), Biol. Reprod., 67, 1435-1438.

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.99.38	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.99.38	macrophage	testicular	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.99.38	cholesterol + AH2 + O2	expression of 25-hydroxylase mRNA and production of 25-hydroxycholesterol by cultured testicular macrophages is significantly inhibited by testosterone at 0.01 mg/ml	Rattus norvegicus	25-hydroxycholesterol + A + H2O	-	?

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Release 2023.1 (January 2023)