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Literature summary extracted from

  • J๖nsson, T.J.; Murray, M.S.; Johnson, L.C.; Poole, L.B.; Lowther, W.T.
    Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin (2005), Biochemistry, 44, 8634-8642.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.8.98.2 crystals of the wild-type and SeMet forms of ET-hSrx were obtained by the vapor diffusion method. 1.65 A crystal structure of human Srx Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH Homo sapiens repairs the inactivated forms of typical two-Cys peroxiredoxins implicated in hydrogen peroxide-mediated cell signaling peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.98.2 Homo sapiens Q9BYN0
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.98.2
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH repairs the inactivated forms of typical two-Cys peroxiredoxins implicated in hydrogen peroxide-mediated cell signaling Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
 ?
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH the ATP molecule is cleaved between the beta- and gamma-phosphate groups Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase
-
 Homo sapiens
1.8.98.2 Srx
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 Homo sapiens
1.8.98.2 sulphiredoxin
-
 Homo sapiens