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Literature summary extracted from

  • Mani, R.S.; Karimi-Busheri, F.; Fanta, M.; Cass, C.E.; Weinfeld, M.
    Spectroscopic studies of DNA and ATP binding to human polynucleotide kinase: evidence for a ternary complex (2003), Biochemistry, 42, 12077-12084.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.78 beta,gamma-imidoadenosine 5'-triphosphate binds with high affinity, similar to ATP Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.78 57102
-
 1 * 58000, SDS-PAGE, 1 * 57102, calculated Homo sapiens
2.7.1.78 58000
-
 sedimentation equilibrium analysis Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.78 Homo sapiens
-
 bifunctional enzyme with both 5’-DNA kinase and 3’-DNA phosphatase activity
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.1.78 ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA mechanism involves a ternary complex of enzyme, ATP and DNA Homo sapiens
a

Subunits

EC Number Subunits Comment Organism
2.7.1.78 monomer 1 * 58000, SDS-PAGE, 1 * 57102, calculated Homo sapiens