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Literature summary extracted from

  • Wang, L.; Erlandsen, H.; Haavik, J.; Knappskog, P.M.; Stevens, R.C.
    Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neutrotransmitters serotonin and melatonin (2002), Biochemistry, 41, 12569-12574.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.14.16.4 sitting drop vapor diffusion method, X-ray crystal structure of a truncated functional form of enzyme (DELTANH102-DELTACOOH402) with the bound cofactor analogue 7,8-dihydro-L-biopterin Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.4 L-tryptophan substrate inhibition above 0.07 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.16.4 0.0078
-
L-tryptophan doubly truncated enzyme form DELTANH102-DELTACOOH402 Homo sapiens
1.14.16.4 0.0265
-
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin doubly truncated enzyme form DELTANH102-DELTACOOH402 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.4 L-tryptophan + tetrahydropteridine + O2 Homo sapiens rate-determining step of serotonin biosynthesis 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.4 Homo sapiens P17752
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.16.4 recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.4 L-tryptophan + (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin + O2
-
Homo sapiens 5-hydroxy-L-tryptophan + ?
-
?
1.14.16.4 L-tryptophan + tetrahydropteridine + O2 rate-determining step of serotonin biosynthesis Homo sapiens 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.4 TRpOH
-
Homo sapiens