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Literature summary extracted from

  • Szabo, R.; Netzel-Arnett, S.; Hobson, J.P.; Antalis, T.M.; Bugge, T.H.
    Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity (2005), Biochem. J., 290, 231-242.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.109 activated matriptase-3 serine protease domain expressed in insect cells, expression in COS7 cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.109 alpha1 proteinase formation of a stable inhibitor complex Mus musculus
3.4.21.109 alpha2-antiplasmin formation of a stable inhibitor complex Mus musculus
3.4.21.109 antithrombin III formation of a stable inhibitor complex Mus musculus
3.4.21.109 hepatocyte growth factor activator inhibitor I
-
 Mus musculus
3.4.21.109 plasminogen activator inhibitor-1 formation of a stable inhibitor complex Mus musculus
3.4.21.109 Protein C inhibitor formation of a stable inhibitor complex Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.109 240
-
 Suc-Ala-Ala-Pro-Arg-p-nitroanilide
-
 Mus musculus
3.4.21.109 534
-
 Suc-Ala-Ala-Pro-Lys-p-nitroanilide
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.109 cell surface
-
 Mus musculus 9986
-
3.4.21.109 membrane transmembrane protein, composed of a short N-terminal cytoplasmic region followed by a transmembrane domain Mus musculus 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.109 90000
-
 x * 90000, SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.109 Homo sapiens
-
-
-
3.4.21.109 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.109 glycoprotein N-glycosylated Mus musculus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.109 activated matriptase-3 serine protease domain expressed in Spodoptera frugiperda Sf9 cells Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.109 brain
-
 Mus musculus
-
3.4.21.109 brain
-
 Homo sapiens
-
3.4.21.109 epididymis
-
 Mus musculus
-
3.4.21.109 eye
-
 Mus musculus
-
3.4.21.109 heart
-
 Mus musculus
-
3.4.21.109 lung
-
 Homo sapiens
-
3.4.21.109 ovary
-
 Mus musculus
-
3.4.21.109 ovary
-
 Homo sapiens
-
3.4.21.109 prostate
-
 Mus musculus
-
3.4.21.109 salivary gland
-
 Mus musculus
-
3.4.21.109 salivary gland
-
 Homo sapiens
-
3.4.21.109 skeletal muscle
-
 Mus musculus
-
3.4.21.109 skin
-
 Mus musculus
-
3.4.21.109 testis
-
 Mus musculus
-
3.4.21.109 testis
-
 Homo sapiens
-
3.4.21.109 thymus
-
 Mus musculus
-
3.4.21.109 trachea
-
 Homo sapiens
-
3.4.21.109 uterus
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.109 Bovine serum albumin + H2O
-
 Mus musculus ?
-
 ?
3.4.21.109 casein + H2O
-
 Mus musculus ?
-
 ?
3.4.21.109 denatured collagen + H2O
-
 Mus musculus ?
-
 ?
3.4.21.109 H-Glu-Gly-Arg-p-nitroanilide + H2O low activity Mus musculus H-Glu-Gly + Arg-p-nitroanilide
-
 ?
3.4.21.109 Suc-Ala-Ala-Pro-Arg-p-nitroanilide + H2O low activity Mus musculus Suc-Ala-Ala-Pro + Arg-p-nitroanilide
-
 ?
3.4.21.109 Suc-Ala-Ala-Pro-Lys-p-nitroanilide + H2O
-
 Mus musculus Suc-Ala-Ala-Pro-Lys + p-nitroaniline
-
 ?
3.4.21.109 Z-Phe-Val-Arg-p-nitroanilide + H2O
-
 Mus musculus Z-Phe-Val + Arg-p-nitroanilide
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.109 ? x * 90000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.4.21.109 matriptase-3
-
 Mus musculus
3.4.21.109 matriptase-3
-
 Homo sapiens