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Literature summary extracted from

  • Kloor, D.; Karnahl, K.; Kompf, J.
    Characterization of glycine N-methyltransferase from rabbit liver (2004), Biochem. Cell Biol., 82, 369-374.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.20 2'-deoxyadenosine
-
 Oryctolagus cuniculus
2.1.1.20 3-deazaadenosine
-
 Oryctolagus cuniculus
2.1.1.20 5'-N-ethylcarboxamidoadenosine
-
 Oryctolagus cuniculus
2.1.1.20 5'-S-isobutylthio-5'-deoxyadenosine
-
 Oryctolagus cuniculus
2.1.1.20 aciclovir
-
 Oryctolagus cuniculus
2.1.1.20 adenosine
-
 Oryctolagus cuniculus
2.1.1.20 AMP
-
 Oryctolagus cuniculus
2.1.1.20 Gly at very high concentrations Oryctolagus cuniculus
2.1.1.20 S-adenosyl-L-homocysteine
-
 Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.20 0.2
-
 S-adenosyl-L-methionine pH 8.6 Oryctolagus cuniculus
2.1.1.20 1
-
 Gly pH 8.6 Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.20 130000
-
 gel filtration Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.20 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.20
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.20 liver
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.20 0.5
-
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.20 S-adenosyl-L-methionine + glycine
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + sarcosine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.20 8.6
-
-
 Oryctolagus cuniculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.1.1.20 7.5 9.5 pH 7.5: about 40% of maximal activity, pH 9.5: about 45% of maximal activity Oryctolagus cuniculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.20 0.03
-
 S-adenosyl-L-homocysteine pH 8.6 Oryctolagus cuniculus
2.1.1.20 0.056
-
 5'-S-isobutylthio-5'-deoxyadenosine pH 8.6 Oryctolagus cuniculus
2.1.1.20 0.21
-
 adenosine pH 8.6 Oryctolagus cuniculus
2.1.1.20 0.28
-
 aciclovir pH 8.6 Oryctolagus cuniculus
2.1.1.20 0.38
-
 2'-deoxyadenosine pH 8.6 Oryctolagus cuniculus
2.1.1.20 0.51
-
 5'-N-ethylcarboxamidoadenosine pH 8.6 Oryctolagus cuniculus
2.1.1.20 0.9
-
 3-deazaadenosine pH 8.6 Oryctolagus cuniculus
2.1.1.20 4.5
-
 AMP pH 8.6 Oryctolagus cuniculus