Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Schroeder, P.; Voevodskaya, N.; Klotz, L.O.; Brenneisen, P.; Graslund, A.; Sies, H.
    Loss of the tyrosyl radical in mouse ribonucleotide reductase by (-)-epicatechin (2005), Biochem. Biophys. Res. Commun., 326, 614-617.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.1 (-)-epicatechin interacts with the R2 protein, leading to a loss of the tyrosyl radical EPR signal. Proliferation of cells exposed to (-)-epicatechin is downregulated, and deoxyribonucleotide levels are significantly diminished Homo sapiens
1.17.4.1 (-)-epicatechin interacts with the R2 protein, leading to a loss of the tyrosyl radical EPR signal. Proliferation of cells exposed to (-)-epicatechin is downregulated, and deoxyribonucleotide levels are significantly diminished Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Homo sapiens
-
-
-
1.17.4.1 Mus musculus
-
 recombinant enzyme
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.1 carcinoma cell squamous Homo sapiens
-
1.17.4.1 keratinocyte
-
 Homo sapiens
-