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Literature summary extracted from

  • Yang, Y.; Eggertsen, G.; Gafvels, M.; Andersson, U.; Einarsson, C.; Bjorkhem, I.; Chiang, J.Y.
    Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1) (2004), Biochem. Biophys. Res. Commun., 320, 1204-1210.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.139 additional information Mus musculus sterol regulatory element binding proteins 1a and 1c enhance transcription of the CYP8B1 gene through binding to sterol regulatory element. Cholesterol loading reduces sterol regulatory element binding proteins 1 mRNA expression in addition to reducing functional sterol regulatory element binding proteins 1 protein, and results in decreasing CYP8B1 gene transcription ?
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1.14.14.139 additional information Rattus norvegicus sterol regulatory element binding proteins 1a and 1c enhance transcription of the CYP8B1 gene through binding to sterol regulatory element. Cholesterol loading reduces sterol regulatory element binding proteins 1 mRNA expression in addition to reducing functional sterol regulatory element binding proteins 1 protein, and results in decreasing CYP8B1 gene transcription ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.139 Mus musculus
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1.14.14.139 Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.139 additional information sterol regulatory element binding proteins 1a and 1c enhance transcription of the CYP8B1 gene through binding to sterol regulatory element. Cholesterol loading reduces sterol regulatory element binding proteins 1 mRNA expression in addition to reducing functional sterol regulatory element binding proteins 1 protein, and results in decreasing CYP8B1 gene transcription Mus musculus ?
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 ?
1.14.14.139 additional information sterol regulatory element binding proteins 1a and 1c enhance transcription of the CYP8B1 gene through binding to sterol regulatory element. Cholesterol loading reduces sterol regulatory element binding proteins 1 mRNA expression in addition to reducing functional sterol regulatory element binding proteins 1 protein, and results in decreasing CYP8B1 gene transcription Rattus norvegicus ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.139 sterol 12alpha-hydroxylase CYP8B1
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 Mus musculus
1.14.14.139 sterol 12alpha-hydroxylase CYP8B1
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 Rattus norvegicus