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Literature summary extracted from

  • Hamdan-Khalil, R.; Allorge, D.; Lo-Guidice, J.M.; Cauffiez, C.; Chevalier, D.; Spire, C.; Houdret, N.; Libersa, C.; Lhermitte, M.; Colombel, J.F.; Gala, J.L.; Broly, F.
    In vitro characterization of four novel non-functional variants of the thiopurine S-methyltransferase (2003), Biochem. Biophys. Res. Commun., 309, 1005-1010.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.67 medicine the knowledge of the genetic basis of interindividual variability in thiopurine S-methyltransferase activity could enhance the efficiency of genotyping methods to preduct patients at risk of inadequate response to thiopurine therapy Homo sapiens
2.1.1.67 medicine the knowledge of the genetic basis of interindividual variability in thiopurine S-methyltransferase activity could enhance the efficiency of genotyping methods to product patients at risk of inadequate response to thiopurine therapy Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.67 0.0349
-
 6-thioguanine
-
 Homo sapiens
2.1.1.67 0.0555
-
 6-thioguanine the Km-value of the variant Ser125Leu is 1.6fold higher than the Km-value of the wild-type variant, the ratio of Vmax to Km-value is 27% of the wild-type ratio Homo sapiens
2.1.1.67 0.0635
-
 6-thioguanine the Km-value of the variant Gly144Arg is 1.8fold higher than the Km-value of the wild-type variant, the ratio of Vmax to Km-value is 31% of the wild-type ratio Homo sapiens
2.1.1.67 0.0759
-
 6-thioguanine the Km-value of the variant Glu28Val is 2.2fold higher than the Km-value of the wild-type variant, the ratio of Vmax to KM-value is 58% of the wild-type ratio Homo sapiens
2.1.1.67 0.1799
-
 6-thioguanine the Km-value of the variant Gly144Arg is 5.1fold higher than the Km-value of the wild-type variant, the ratio of Vmax to KM-value is 10.4% of the wild-type ratio Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
 natural variant Glu28Val, TPMT*13
-
2.1.1.67 Homo sapiens
-
 natural variant Gly144Arg, variant TPMT*10
-
2.1.1.67 Homo sapiens
-
 natural variant His227Gln, variant TPMT*7
-
2.1.1.67 Homo sapiens
-
 natural variant Ser125Leu, variant TPMT*12
-
2.1.1.67 Homo sapiens
-
 wild-type variant
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.67 TPMT
-
 Homo sapiens