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Literature summary extracted from

  • Beum, P.V.; Basma, H.; Bastola, D.R.; Cheng, P.W.
    Mucin biosynthesis: upregulation of core 2 beta 1,6 N-acetylglucosaminyltransferase by retinoic acid and Th2 cytokines in a human airway epithelial cell line (2005), Am. J. Physiol., 288, L116-124.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.148 interleukin-13 upregulation of enzyme expression Homo sapiens
2.4.1.148 interleukin-4 synergistic with retinoic acid in activating the core 4 N-acetylglucosaminyltransferase activity Homo sapiens
2.4.1.148 retinoic acid upregulation of enzyme expression, synergistic with interleukin-4 in activating the core 4 N-acetylglucosaminyltransferase activity Homo sapiens
2.4.1.148 Th2 cytokines upregulation of enzyme expression Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.148 Zn2+ complete inactivation at 10 mM Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.148 Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.102 additional information Homo sapiens M isoform is upregulated by both all-trans retinoic acid and by IL-4/13. L-isoform is moderately upregulated by IL-4/13 but not by all-trans retinoic acid ?
-
 ?
2.4.1.148 additional information Homo sapiens the enzyme is involved in the mucin biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.102 Homo sapiens
-
-
-
2.4.1.148 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.102 NCI-H292 cell airway epithelial cell line Homo sapiens
-
2.4.1.148 epithelium airway epithelial cell line Homo sapiens
-
2.4.1.148 NCI-H292 cell airway epithelial cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.102 additional information M isoform is upregulated by both all-trans retinoic acid and by IL-4/13. L-isoform is moderately upregulated by IL-4/13 but not by all-trans retinoic acid Homo sapiens ?
-
 ?
2.4.1.102 additional information the M isoform of C2GnT can form all mucin glycan beta1,6-branched structures, including core 2, core 4, and blood group I antigen. The L-isoform forms only core 2 structures Homo sapiens ?
-
 ?
2.4.1.148 additional information the enzyme is involved in the mucin biosynthesis Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.102 C2GnT
-
 Homo sapiens
2.4.1.102 core 2 beta1,6 N-acetylglucosaminyltransferase
-
 Homo sapiens
2.4.1.148 C2GnT
-
 Homo sapiens
2.4.1.148 core 2 beta 1,6 N-acetylglucosaminyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.148 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.148 7.5
-
 assay at Homo sapiens