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Literature summary extracted from

  • Flores, E.; Cabeza, M.; Quiroz, A.; Bratoeff, E.; Garcia, G.; Ramirez, E.
    Effect of a novel steroid (PM-9) on the inhibition of 5alpha-reductase present in Penicillium crustosum broths (2003), Steroids, 68, 271-275.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 4-bromo-17alpha-(p-fluorobenzoyloxy)-4-pregnene-3,20-dione competitive Penicillium crustosum
1.3.1.22 finasteride competitive Penicillium crustosum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.22 0.00022
-
 testosterone pH 6.0, 25°C Penicillium crustosum

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Penicillium crustosum
-
 growth on fermented pistachos, lemons and corn tortillas
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 culture supernatant
-
 Penicillium crustosum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 testosterone + NADPH + H+
-
 Penicillium crustosum 17beta-hydroxy-5alpha-androstan-3-one + NADP+
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.22 0.00154
-
 finasteride pH 6.0, 25°C Penicillium crustosum
1.3.1.22 0.0126
-
 4-bromo-17alpha-(p-fluorobenzoyloxy)-4-pregnene-3,20-dione pH 6.0, 25°C Penicillium crustosum