BRENDA - Enzyme Database show

Free fatty acids inhibit the activity of Clostridium histolyticum collagenase and human neutrophil elastase

Rennert, B.; Melzig, M.F.; Planta Med. 68, 767-769 (2002)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.4.24.3
erucic acid
IC50: 0.415 mM
Hathewaya histolytica
3.4.24.3
heptadecanoic acid
IC50: 0.03 mM
Hathewaya histolytica
3.4.24.3
linoleic acid
IC50: 0.375 mM
Hathewaya histolytica
3.4.24.3
linolenic acid
IC50: 0.46 mM
Hathewaya histolytica
3.4.24.3
additional information
no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid
Hathewaya histolytica
3.4.24.3
myristic acid
IC50: 0.27 mM
Hathewaya histolytica
3.4.24.3
nonadecanoic acid
0.045 mM
Hathewaya histolytica
3.4.24.3
oleic acid
IC50: 0.46 mM
Hathewaya histolytica
3.4.24.3
palmitic acid
IC50: 0.035 mM
Hathewaya histolytica
3.4.24.3
palmitoleic acid
IC50: 0.405 mM
Hathewaya histolytica
3.4.24.3
pentadecanoic acid
IC50: 0.125 mM
Hathewaya histolytica
3.4.24.3
stearic acid
IC50: 0.03 mM
Hathewaya histolytica
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.4.24.3
Hathewaya histolytica
-
-
-
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3.4.24.3
0.03
-
IC50: 0.03 mM
Hathewaya histolytica
heptadecanoic acid
3.4.24.3
0.03
-
IC50: 0.03 mM
Hathewaya histolytica
stearic acid
3.4.24.3
0.035
-
IC50: 0.035 mM
Hathewaya histolytica
cabozantinib
3.4.24.3
0.125
-
IC50: 0.125 mM
Hathewaya histolytica
pentadecanoic acid
3.4.24.3
0.27
-
IC50: 0.27 mM
Hathewaya histolytica
myristic acid
3.4.24.3
0.375
-
IC50: 0.375 mM
Hathewaya histolytica
linoleic acid
3.4.24.3
0.405
-
IC50: 0.405 mM
Hathewaya histolytica
palmitoleic acid
3.4.24.3
0.415
-
IC50: 0.415 mM
Hathewaya histolytica
erucic acid
3.4.24.3
0.46
-
IC50: 0.46 mM
Hathewaya histolytica
linolenic acid
3.4.24.3
0.46
-
IC50: 0.46 mM
Hathewaya histolytica
oleic acid
3.4.24.3
0.5
-
no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid
Hathewaya histolytica
additional information
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3.4.24.3
0.03
-
IC50: 0.03 mM
Hathewaya histolytica
heptadecanoic acid
3.4.24.3
0.03
-
IC50: 0.03 mM
Hathewaya histolytica
stearic acid
3.4.24.3
0.035
-
IC50: 0.035 mM
Hathewaya histolytica
cabozantinib
3.4.24.3
0.125
-
IC50: 0.125 mM
Hathewaya histolytica
pentadecanoic acid
3.4.24.3
0.27
-
IC50: 0.27 mM
Hathewaya histolytica
myristic acid
3.4.24.3
0.375
-
IC50: 0.375 mM
Hathewaya histolytica
linoleic acid
3.4.24.3
0.405
-
IC50: 0.405 mM
Hathewaya histolytica
palmitoleic acid
3.4.24.3
0.415
-
IC50: 0.415 mM
Hathewaya histolytica
erucic acid
3.4.24.3
0.46
-
IC50: 0.46 mM
Hathewaya histolytica
linolenic acid
3.4.24.3
0.46
-
IC50: 0.46 mM
Hathewaya histolytica
oleic acid
3.4.24.3
0.5
-
no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid
Hathewaya histolytica
additional information
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.4.24.3
erucic acid
IC50: 0.415 mM
Hathewaya histolytica
3.4.24.3
heptadecanoic acid
IC50: 0.03 mM
Hathewaya histolytica
3.4.24.3
linoleic acid
IC50: 0.375 mM
Hathewaya histolytica
3.4.24.3
linolenic acid
IC50: 0.46 mM
Hathewaya histolytica
3.4.24.3
additional information
no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid
Hathewaya histolytica
3.4.24.3
myristic acid
IC50: 0.27 mM
Hathewaya histolytica
3.4.24.3
nonadecanoic acid
0.045 mM
Hathewaya histolytica
3.4.24.3
oleic acid
IC50: 0.46 mM
Hathewaya histolytica
3.4.24.3
palmitic acid
IC50: 0.035 mM
Hathewaya histolytica
3.4.24.3
palmitoleic acid
IC50: 0.405 mM
Hathewaya histolytica
3.4.24.3
pentadecanoic acid
IC50: 0.125 mM
Hathewaya histolytica
3.4.24.3
stearic acid
IC50: 0.03 mM
Hathewaya histolytica