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Literature summary extracted from

  • Hauschild, R.; von Schaewen, A.
    Differential regulation of glucose-6-phosphate dehydrogenase isoenzyme activities in potato (2003), Plant Physiol., 133, 47-62.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.49 additional information light and metabolizable sugars induce the cytosolic isozyme by increased de novo protein synthesis, while the plastidic isozymes are unaffected Solanum tuberosum
1.1.1.49 paraquat activates plastidic isozymes by 10fold by direct action on the enzyme, no activation of the cytosolic isozyme Solanum tuberosum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.49 cytosolic isozyme, DNA sequence determination, expression in Escherichia coli Solanum tuberosum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.49 3-(3,4-dichlorophenyl)-1,1'-dimethyl urea cytosolic isozyme, inhibition by uncoupling of photosynthetic electron transport Solanum tuberosum
1.1.1.49 cycloheximide
-
 Solanum tuberosum
1.1.1.49 additional information the cytosolic isoyzme is not affected by osmotic change, phosphate sequestration, or ocidative stress Solanum tuberosum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.49 cytosol
-
 Solanum tuberosum 5829
-
1.1.1.49 plastid plastidic isozymes P1 and P2 are regulated by redox regulation Solanum tuberosum 9536
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.49 additional information no effect on cytosolic isozyme by H2O2, FeCl3, NH4Cl, NaNO2, NaNO3, sulfate or endothall, okadaic acid and NaF Solanum tuberosum
1.1.1.49 nitrate activates plastidic isozymes by 10fold by direct action on the enzyme Solanum tuberosum
1.1.1.49 nitrite activates plastidic isozymes by 10fold by direct action on the enzyme Solanum tuberosum
1.1.1.49 sulfate activates plastidic isozymes by 10fold by direct action on the enzyme Solanum tuberosum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.49 D-glucose 6-phosphate + NADP+ Solanum tuberosum differential regulation of isozymes, the cytosolic enzyme is regulated by sugar availability at transcriptional level, while the plastidic isozymes are regulated by redox mechanism D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.49 Solanum tuberosum
-
 4 weeks-old plants, isozymes in plastid, P1 and P2, and cytosol
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.49 leaf
-
 Solanum tuberosum
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.49 additional information
-
 assay under nitrogen atmosphere Solanum tuberosum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.49 D-glucose 6-phosphate + NADP+
-
 Solanum tuberosum D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
 ?
1.1.1.49 D-glucose 6-phosphate + NADP+ differential regulation of isozymes, the cytosolic enzyme is regulated by sugar availability at transcriptional level, while the plastidic isozymes are regulated by redox mechanism Solanum tuberosum D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.49 G6PDH
-
 Solanum tuberosum
1.1.1.49 glucose-6-phosphate dehydrogenase
-
 Solanum tuberosum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.49 8
-
 assay at Solanum tuberosum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.49 NADP+
-
 Solanum tuberosum