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Literature summary extracted from

  • Dalal, S.; Rosser, M.F.N.; Cyr, D.M.; Hanson, P.I.
    Distinct roles for the AAA ATPases NSF and p97 in the secretory pathway (2004), Mol. Biol. Cell, 15, 637-648.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.4.6 expression in Escherichia coli Mus musculus
3.6.4.6 expression in U2OS TRex cells Cricetulus griseus

Protein Variants

EC Number Protein Variants Comment Organism
3.6.4.6 E305Q mutant assembles into oligomer like wild-type, similar ATPase activity as wild-type Mus musculus
3.6.4.6 E305Q/E578Q no ATPase activity Mus musculus
3.6.4.6 E329Q in contrast to wild-type NFS E329Q mutant is enriched on various structures throughout the cell and is only minimally released by saponin permeabilization Cricetulus griseus
3.6.4.6 E578Q mutant assembles into oligomer like wild-type, severely impaired ATPase activity Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.4.6 cytosol
-
 Cricetulus griseus 5829
-
3.6.4.6 cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.4.6 ATP + H2O Cricetulus griseus
-
 ADP + phosphate
-
 ?
3.6.4.6 ATP + H2O Mus musculus
-
 ADP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.4.6 Cricetulus griseus
-
-
-
3.6.4.6 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.4.6 ATP + H2O
-
 Cricetulus griseus ADP + phosphate
-
 ?
3.6.4.6 ATP + H2O
-
 Mus musculus ADP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.4.6 N-ethyl maleimide sensitive factor
-
 Cricetulus griseus
3.6.4.6 NSF
-
 Cricetulus griseus