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Literature summary extracted from

  • Bork, S.; Okamura, M.; Boonchit, S.; Hirata, H.; Yokoyama, N.; Igarashi, I.
    Identification of Babesia bovis L-lactate dehydrogenase as a potential chemotherapeutical target against bovine babesiosis (2004), Mol. Biochem. Parasitol., 136, 165-172.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.27 medicine suitable drug target for design of novel babesial chemotherapeutics Babesia bovis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.27
-
 Babesia bovis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.27 gossypol competitive with NADH Babesia bovis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.27 0.0081
-
 NADH
-
 Babesia bovis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.27 cytoplasm of intra- and extraerythrocytic parasites Babesia bovis 5737
-
1.1.1.27 membrane of infected erythrocytes Babesia bovis 16020
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.27 Babesia bovis Q7Z0X7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.27 pyruvate + NADH + H+
-
 Babesia bovis (S)-lactate + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.27 BbLDH
-
 Babesia bovis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.27 216.7
-
 NADH
-
 Babesia bovis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.27 NADH
-
 Babesia bovis