BRENDA - Enzyme Database show

Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients

Nakata, T.; Takashima, S.; Shiotsu, Y.; Murakata, C.; Ishida, H.; Akinaga, S.; Li, P.K.; Sasano, H.; Suzuki, T.; Saeki, T.; J. Steroid Biochem. Mol. Biol. 86, 455-460 (2003)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
3.1.6.2
medicine
the expression of STS is an independent prognostic factor in breast cancer, STS is a new molecular target for the treatment of estrogen-dependent breast tumor post-selective estrogen receptor modulator and/or aromatase inhibitors
Homo sapiens
3.1.6.2
pharmacology
the non-estrogenic STS inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine has anti-cancer activity and should be a potent therapeutic agent for treatment of estrogen-dependent breast cancer
Homo sapiens
Cloned(Commentary)
EC Number
Commentary
Organism
3.1.6.2
overexpression of STS gene in human breast cancer MCF-7 cells, i.e. MCS-2 cells, transplanted in female nude mice
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.6.2
(p-O-sulfamoyl)-N-tetradecanoyl tyramine
non-estrogenic STS inhibitor, IC50: 56 nM/l, anti-cancer activity
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.6.2
additional information
Homo sapiens
biosynthesis of estrogens in breast tumor tissues of post-menopausal breast cancer patients, STS stimulates the growth and survival of estrogen-dependent breast tumors
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.6.2
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.6.2
MCS-2 cell
the MCS-2 cell line is established by introduction of the human STS gene into estrogen-dependent human breast cancer MCF-7 cells, MCS-2 cells are transplanted into female nude mice
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.6.2
androstenediol sulfate + H2O
-
656653
Homo sapiens
androstenediol + sulfate
-
-
-
?
3.1.6.2
dehydroepiandrosterone sulfate + H2O
-
656653
Homo sapiens
dehydroepiandrosterone + sulfate
-
-
-
?
3.1.6.2
estrone 3-sulfate + H2O
-
656653
Homo sapiens
estrone + sulfate
-
-
-
?
3.1.6.2
additional information
biosynthesis of estrogens in breast tumor tissues of post-menopausal breast cancer patients, STS stimulates the growth and survival of estrogen-dependent breast tumors
656653
Homo sapiens
?
-
-
-
-
Application (protein specific)
EC Number
Application
Commentary
Organism
3.1.6.2
medicine
the expression of STS is an independent prognostic factor in breast cancer, STS is a new molecular target for the treatment of estrogen-dependent breast tumor post-selective estrogen receptor modulator and/or aromatase inhibitors
Homo sapiens
3.1.6.2
pharmacology
the non-estrogenic STS inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine has anti-cancer activity and should be a potent therapeutic agent for treatment of estrogen-dependent breast cancer
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.6.2
overexpression of STS gene in human breast cancer MCF-7 cells, i.e. MCS-2 cells, transplanted in female nude mice
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.6.2
(p-O-sulfamoyl)-N-tetradecanoyl tyramine
non-estrogenic STS inhibitor, IC50: 56 nM/l, anti-cancer activity
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.6.2
additional information
Homo sapiens
biosynthesis of estrogens in breast tumor tissues of post-menopausal breast cancer patients, STS stimulates the growth and survival of estrogen-dependent breast tumors
?
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.6.2
MCS-2 cell
the MCS-2 cell line is established by introduction of the human STS gene into estrogen-dependent human breast cancer MCF-7 cells, MCS-2 cells are transplanted into female nude mice
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.6.2
androstenediol sulfate + H2O
-
656653
Homo sapiens
androstenediol + sulfate
-
-
-
?
3.1.6.2
dehydroepiandrosterone sulfate + H2O
-
656653
Homo sapiens
dehydroepiandrosterone + sulfate
-
-
-
?
3.1.6.2
estrone 3-sulfate + H2O
-
656653
Homo sapiens
estrone + sulfate
-
-
-
?
3.1.6.2
additional information
biosynthesis of estrogens in breast tumor tissues of post-menopausal breast cancer patients, STS stimulates the growth and survival of estrogen-dependent breast tumors
656653
Homo sapiens
?
-
-
-
-