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Literature summary extracted from

  • Nakata, T.; Takashima, S.; Shiotsu, Y.; Murakata, C.; Ishida, H.; Akinaga, S.; Li, P.K.; Sasano, H.; Suzuki, T.; Saeki, T.
    Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients (2003), J. Steroid Biochem. Mol. Biol., 86, 455-460.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.6.2 medicine the expression of STS is an independent prognostic factor in breast cancer, STS is a new molecular target for the treatment of estrogen-dependent breast tumor post-selective estrogen receptor modulator and/or aromatase inhibitors Homo sapiens
3.1.6.2 pharmacology the non-estrogenic STS inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine has anti-cancer activity and should be a potent therapeutic agent for treatment of estrogen-dependent breast cancer Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.6.2 overexpression of STS gene in human breast cancer MCF-7 cells, i.e. MCS-2 cells, transplanted in female nude mice Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.2 (p-O-sulfamoyl)-N-tetradecanoyl tyramine non-estrogenic STS inhibitor, IC50: 56 nM/l, anti-cancer activity Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.2 additional information Homo sapiens biosynthesis of estrogens in breast tumor tissues of post-menopausal breast cancer patients, STS stimulates the growth and survival of estrogen-dependent breast tumors ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.2 MCS-2 cell the MCS-2 cell line is established by introduction of the human STS gene into estrogen-dependent human breast cancer MCF-7 cells, MCS-2 cells are transplanted into female nude mice Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.2 androstenediol sulfate + H2O
-
 Homo sapiens androstenediol + sulfate
-
 ?
3.1.6.2 dehydroepiandrosterone sulfate + H2O
-
 Homo sapiens dehydroepiandrosterone + sulfate
-
 ?
3.1.6.2 estrone 3-sulfate + H2O
-
 Homo sapiens estrone + sulfate
-
 ?
3.1.6.2 additional information biosynthesis of estrogens in breast tumor tissues of post-menopausal breast cancer patients, STS stimulates the growth and survival of estrogen-dependent breast tumors Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.6.2 STS
-
 Homo sapiens