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Literature summary extracted from

  • Watkins, W.E.; Glass, T.L.
    Characteristics of 16-dehydroprogesterone reductase in cell extracts of the intestinal anaerobe, Eubacterium sp. strain 144 (1991), J. Steroid Biochem., 38, 257-263.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.98 sulfhydryl reagents
-
 Eubacterium sp.
4.2.1.98 Tris-HCl at pH above 7.0 Eubacterium sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.98 cytoplasm 40% of the activity Eubacterium sp. 5737
-
4.2.1.98 membrane 20% of the activity Eubacterium sp. 16020
-

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.98 Eubacterium sp.
-
-
-
4.2.1.98 Eubacterium sp. 144
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.98 16alpha-hydroxyprogesterone pyruvate or Na dithionite serve as electron donor and both reactions require methyl viologen as an electron carrier Eubacterium sp. 16,17-didehydroprogesterone + H2O
-
 ?
4.2.1.98 16alpha-hydroxyprogesterone pyruvate or Na dithionite serve as electron donor and both reactions require methyl viologen as an electron carrier Eubacterium sp. 144 16,17-didehydroprogesterone + H2O
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.98 5 8.5 activity is unaffected by pH in potassium phosphate buffer over the range pH 5.0-8.5 Eubacterium sp.