Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Moreb, J.S.; Gabr, A.; Vartikar, G.R.; Gowda, S.; Zucali, J.R.; Mohuczy, D.
    Retinoic acid down-regulates aldehyde dehydrogenase and increases cytotoxicity of 4-hydroperoxycyclophosphamide and acetaldehyde (2005), J. Pharmacol. Exp. Ther., 312, 339-345.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.2.1.36 medicine retinoic acid down-regulates aldehyde dehydrogenase and increases cytotoxicity of 4-hydroperoxycyclophosphamide and acetaldehyde in lung cancer cell lines Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.36 retinal + NAD+ + H2O Homo sapiens
-
 retinoate + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.36 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.36 A-549 cell lung cancer Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.36 retinal + NAD+ + H2O
-
 Homo sapiens retinoate + NADH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.36 ALDH-1A1 ambiguous Homo sapiens
1.2.1.36 ALDH-3A1 ambiguous Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.36 NAD+
-
 Homo sapiens