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Literature summary extracted from

  • Kindzelskii, A.L.; Ueki, T.; Michibata, H.; Chaiworapongsa, T.; Romero, R.; Petty, H.R.
    6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase form a supramolecular complex in human neutrophils that undergoes retrograde trafficking during pregnancy (2004), J. Immunol., 172, 6373-6381.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.43 additional information
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.43 6-phosphono-D-gluconate + NAD(P)+ Homo sapiens second step of hexose monophosphate shunt, i.e. HMS 6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.43 Homo sapiens
-
 pregnant and nonpregnant women
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.43 neutrophil of pregnant and nonpregnant women, enzyme undergoes retrograde transport to the microtubule-organizing centers in neutrophils from pregnant women, can be blocked by colchicine, anterograde distribution in cells from nonpregnant women Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.43 6-phospho-D-gluconate + NAD(P)+
-
 Homo sapiens 6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
 ?
1.1.1.43 6-phosphono-D-gluconate + NAD(P)+ second step of hexose monophosphate shunt, i.e. HMS Homo sapiens 6-phospho-2-dehydro-D-gluconate + NAD(P)H
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.43 6-PGDase
-
 Homo sapiens
1.1.1.43 6-phosphogluconate dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.43 NAD+
-
 Homo sapiens
1.1.1.43 NADP+
-
 Homo sapiens