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Literature summary extracted from
- Measurement of endogenous uracil and dihydrouracil in plasma and urine of normal subjects by liquid chromatography-tandem mass spectrometry (2002), J. Chromatogr. B, 769, 169-176.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.1 | 5,6-dihydrouracil + NAD+ | Homo sapiens | - |
uracil + NADH + H+ | - |
r |  |
| 1.3.1.1 | 5-fluorouracil + NAD+ | Homo sapiens | rate-limiting step in the elimination of the chemotherapeutic drug fluoropyrimidine | ? + NADH | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.1.1 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.3.1.1 | bone marrow | - |
Homo sapiens | - |
| 1.3.1.1 | intestine | mucosa | Homo sapiens | - |
| 1.3.1.1 | liver | - |
Homo sapiens | - |
| 1.3.1.1 | mononuclear cell | peripheral blood | Homo sapiens | - |
| 1.3.1.1 | mucosa | intestine | Homo sapiens | - |
| 1.3.1.1 | plasma | - |
Homo sapiens | - |
| 1.3.1.1 | spleen | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.3.1.1 | additional information | - |
development of a quantitative assay method, determination of substrate and product in plasma and urine samples, overview | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.1 | 5,6-dihydrouracil + NAD+ | - |
Homo sapiens | uracil + NADH + H+ | - |
r | |
| 1.3.1.1 | 5-fluorouracil + NAD+ | - |
Homo sapiens | ? + NADH | - |
r | |
| 1.3.1.1 | 5-fluorouracil + NAD+ | rate-limiting step in the elimination of the chemotherapeutic drug fluoropyrimidine | Homo sapiens | ? + NADH | - |
r | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.3.1.1 | dihydropyrimidine dehydrogenase | - |
Homo sapiens |
| 1.3.1.1 | DPD | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.1 | NAD+ | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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