Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wadud, S.; Or-Rashid, M.M.; Onodera, R.
    Method for determination of histidine in tissues by isocratic high-performance liquid chromatography and its application to the measurement of histidinol dehydrogenase activity in six cattle organs (2002), J. Chromatogr. B, 767, 369-374.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.23 L-histidinal + NAD+ + H2O Bos taurus enzyme is responsible for catalysis of the terminal step in L-histidine biosynthesis, being performed in 2 sequential reactions via the intermediate L-histidinal L-histidine + NADH + H+
-
 ir
1.1.1.23 L-histidinol + NAD+ Bos taurus enzyme is responsible for catalysis of the terminal step in L-histidine biosynthesis, being performed in 2 sequential reactions via the intermediate L-histidinal L-histidinal + NADH + H+
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.23 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.23 L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+ also oxidizes L-histidinal Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.23 kidney
-
 Bos taurus
-
1.1.1.23 liver highest activity Bos taurus
-
1.1.1.23 additional information activity in the organs in descending order: liver, kidney, pancreas, spleen, skeletal muscle, small intestine Bos taurus
-
1.1.1.23 pancreas
-
 Bos taurus
-
1.1.1.23 skeletal muscle low activity Bos taurus
-
1.1.1.23 small intestine very low activity Bos taurus
-
1.1.1.23 spleen low activity Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.23 additional information
-
 the activity of the enzyme in different tissues at different pH values, development of a determination method for quantification of L-histidinol and L-histidine using isocratic HPLC, overview Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.23 L-histidinal + NAD+ + H2O
-
 Bos taurus L-histidine + NADH + H+
-
 ir
1.1.1.23 L-histidinal + NAD+ + H2O enzyme is responsible for catalysis of the terminal step in L-histidine biosynthesis, being performed in 2 sequential reactions via the intermediate L-histidinal Bos taurus L-histidine + NADH + H+
-
 ir
1.1.1.23 L-histidinol + NAD+
-
 Bos taurus L-histidinal + NADH + H+
-
 ir
1.1.1.23 L-histidinol + NAD+ enzyme is responsible for catalysis of the terminal step in L-histidine biosynthesis, being performed in 2 sequential reactions via the intermediate L-histidinal Bos taurus L-histidinal + NADH + H+
-
 ir

Synonyms

EC Number Synonyms Comment Organism
1.1.1.23 HLDase
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.23 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.23 additional information
-
 the activity of the enzyme in different tissues is differently regulated with respect to the pH value, overview Bos taurus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.23 8 12
-
 Bos taurus