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Literature summary extracted from

  • Papini, N.; Anastasia, L.; Tringali, C.; Croci, G.; Bresciani, R.; Yamaguchi, K.; Miyagi, T.; Preti, A.; Prinetti, A.; Prioni, S.; Sonnino, S.; Tettamanti, G.; Venerando, B.; Monti, E.
    The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactions (2004), J. Biol. Chem., 279, 16989-16995.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.1.18 C-terminally HA-tagged enzyme, transient functional overexpression in COS-7 cells, location at the cell surface in the plasma membrane Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.18 plasma membrane associated, cell-surface location Mus musculus 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.18 ganglioside GD1a + H2O Mus musculus in transfected cells, mainly via cell-cell-interaction ganglioside GM1 + sialic acid
-
 ?
3.2.1.18 ganglioside GM3 + H2O Mus musculus in transfected cells, mainly via cell-cell-interaction sialic acid + ?
-
 ?
3.2.1.18 additional information Mus musculus the enzyme modifies the ganglioside pattern of adjacent cells, involved in cell-cell-interaction ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.18 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.18 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O
-
 Mus musculus 4-methylumbelliferol + alpha-D-N-acetylneuraminic acid
-
 ?
3.2.1.18 ganglioside GD1a + H2O in transfected cells, mainly via cell-cell-interaction Mus musculus ganglioside GM1 + sialic acid
-
 ?
3.2.1.18 ganglioside GD1a + H2O
-
 Mus musculus sialic acid + ?
-
 ?
3.2.1.18 ganglioside GM3 + H2O
-
 Mus musculus sialic acid + ?
-
 ?
3.2.1.18 ganglioside GM3 + H2O in transfected cells, mainly via cell-cell-interaction Mus musculus sialic acid + ?
-
 ?
3.2.1.18 additional information the enzyme modifies the ganglioside pattern of adjacent cells, involved in cell-cell-interaction Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.18 MmNEU3
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.18 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.18 3.8
-
 assay at Mus musculus