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Literature summary extracted from
- Mechanism of superoxide and hydrogen peroxide formation by fumarate reductase, succinate dehydrogenase, and aspartate oxidase (2002), J. Biol. Chem., 277, 42563-42571.
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.5.1 | Iron | contains [2Fe-2S], [4Fe-4S] and [3Fe-4S] clusters | Escherichia coli |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.5.1 | succinate + acceptor | Escherichia coli | - |
fumarate + reduced acceptor | - |
? | |
| 1.4.3.16 | L-aspartate + H2O + fumarate | Escherichia coli | it is very likely, that fumarate and not O2 is the physiological electron acceptor in vivo | oxaloacetate + NH3 + succinate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.5.1 | Escherichia coli | - |
- |
- |
| 1.4.3.16 | Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.5.1 | succinate + acceptor | - |
Escherichia coli | fumarate + reduced acceptor | - |
? | |
| 1.3.5.1 | succinate + acceptor | Sdh produces only superoxide and no H2O2 upon flavin autoxidation, even at high concentrations of succinate | Escherichia coli | fumarate + reduced acceptor | - |
? | |
| 1.4.3.16 | L-aspartate + H2O + fumarate | - |
Escherichia coli | oxaloacetate + NH3 + succinate | - |
? | |
| 1.4.3.16 | L-aspartate + H2O + fumarate | it is very likely, that fumarate and not O2 is the physiological electron acceptor in vivo | Escherichia coli | oxaloacetate + NH3 + succinate | - |
? | |
| 1.4.3.16 | L-aspartate + H2O + O2 | oxidation is accelerated in the presence of 0.5 mM fumarate, fumarate appears to be the preferred electron acceptor since its presence inhibits oxygen reduction by 90% | Escherichia coli | oxaloacetate + NH3 + H2O2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.3.5.1 | SDH | - |
Escherichia coli |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.16 | FAD | - |
Escherichia coli | |
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Release 2023.1 (January 2023)
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