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Literature summary extracted from

  • Kang, S.W.; Chae, H.Z.; Seo, M.S.; Kim, K.; Baines, I.C.; Rhee, S.G.
    Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha (1998), J. Biol. Chem., 273, 6297-6302.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.11.1.24 expression of Prx I, Prx II and Prx III in Escherichia coli Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.11.1.24 cytosol Prx I and Prx II Homo sapiens 5829
-
1.11.1.24 mitochondrion Prx III Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.24 additional information Homo sapiens together with glutathione peroxidase and catalase, Prx enzymes likely play an important role in eliminating peroxides generated during metabolism. In addition Prx I and II might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentration of H2O2 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.24 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.24 H2O2 + reduced thioredoxin
-
 Homo sapiens H2O + oxidized thioredoxin
-
 ?
1.11.1.24 additional information together with glutathione peroxidase and catalase, Prx enzymes likely play an important role in eliminating peroxides generated during metabolism. In addition Prx I and II might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentration of H2O2 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.24 Prx I
-
 Homo sapiens
1.11.1.24 Prx II
-
 Homo sapiens
1.11.1.24 Prx III
-
 Homo sapiens