Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Thomas, J.A.; Nakai, C.
    Control of glycogen synthase phosphatase from rat heart (1973), J. Biol. Chem., 248, 2208-2213.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.42 Ca2+ 5 mM, 2.4fold activation Rattus norvegicus
3.1.3.42 D-glucosamine 6-phosphate 2 mM, 30°C, pH 7.8, 3.2fold activation Rattus norvegicus
3.1.3.42 D-glucose 1-phosphate 2 mM, 30°C, pH 7.8, 3.8fold activation Rattus norvegicus
3.1.3.42 D-glucose 6-phosphate 4.9fold activation, without D-glucose 6-phosphate 38.8% remainimng activity and additionally without D-glucose 6-phosphate 23.1% remaining activity Rattus norvegicus
3.1.3.42 Mg2+ 5 mM, 3.7fold activation, without Mg2+ 33% remaining activity and additionally without D-glucose 6-phosphate 23.1% remaining activity Rattus norvegicus
3.1.3.42 Mn2+ 5 mM, 4.4fold activation Rattus norvegicus
3.1.3.42 additional information no effects of 5 mM K+ and Na+, and 2 mM 6-P-gluconate, D-fructose 1,6-bisphosphate, alpha-glycerol phosphate, creatine phosphate, phosphate, and SO42- Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.42 glycogen competitive inhibition with glycogen synthase D as substrate Rattus norvegicus
3.1.3.42 KF 50 mM, 30°C, pH 7.8, complete inhibition Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.42 phosphoprotein phosphatase + H2O Rattus norvegicus
-
 protein + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.42 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.42
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.42 heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.42 glycogen synthase D + H2O
-
 Rattus norvegicus glycogen synthase I + phosphate
-
 ?
3.1.3.42 phosphoprotein phosphatase + H2O
-
 Rattus norvegicus protein + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.42 glycogen synthase phosphatase
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.42 7.3
-
 at 30°C Rattus norvegicus