EC Number | Application | Comment | Organism |
---|---|---|---|
1.1.1.21 | medicine | inhibition of enzyme prevents TNF-alpha-induced increase in Bax and Bak and the downregulation of Bcl-2, inhibition abrogates Ap-1 DNA binding activity and prevents the activation of caspase-3, JNK, and p38 MAPK in cells stimulated by TNFalpha | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.21 | sorbinil | - |
Homo sapiens | |
1.1.1.21 | Tolrestat | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.21 | additional information | Homo sapiens | enzyme is a critical regulator of TNF-alpha-induced apoptotic signaling in endothelial cells | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.21 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.21 | endothelial cell | umbilical vein endothelial cell | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.21 | additional information | enzyme is a critical regulator of TNF-alpha-induced apoptotic signaling in endothelial cells | Homo sapiens | ? | - |
? |