Literature summary extracted from

Garcia-Pelayo, M.C.; Garcia-Peregrin, E.; Martinez-Cayuela, M.
Differential translational effects of myristic acid and eicosapentaenoic acid on 3-hydroxy-3-methylglutaryl-CoA reductase from Reuber H35 hepatoma cells (2004), Exp. Biol. Med., 229, 781-786.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.1.1.34	myristic acid	stimulates translation of the enzyme about 1.8fold at 0.15 mM, upregulation	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.34	cycloheximide	downregulation of protein synthesis, synergistic with eicosapentanoic acid and myristic acid	Homo sapiens
1.1.1.34	eicosapentaenoic acid	inhibits translation of the enzyme about 50% at 0.15 mM, downregulation, slightly increases downregulation of protein synthesis by cycloheximide	Homo sapiens

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
1.1.1.34	52000	56000	proteolytically cleaved soluble enzyme fragment	Homo sapiens
1.1.1.34	96000	-	intact membrane protein	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.34	(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+	Homo sapiens	-	(R)-mevalonate + CoA + 2 NADP+	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.34	Homo sapiens	-	-	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
1.1.1.34	proteolytic modification	proteolysis releases a soluble, active fragment of 52-56 kDa	Homo sapiens

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.34	Reuber H-35 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.34	(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+	-	Homo sapiens	(R)-mevalonate + CoA + 2 NADP+	-	r

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Release 2023.1 (January 2023)