Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Osterlund, T.
    Structure-function relationships of hormone-sensitive lipase (2001), Eur. J. Biochem., 268, 1899-1907.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.79 expression in COS and insect cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.79 cytosol HSL can translocate from the cytosol to the lipid droplet surface upom protein kinase phosphorylation Rattus norvegicus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.79 84032
-
 x * 84032, deduced from nucleotide sequence Homo sapiens
3.1.1.79 84073
-
 x * 84073, deduced from nucleotide sequence, HSL might be a homodimer in solution Rattus norvegicus
3.1.1.79 116000
-
 x * 116000, SDS-PAGE, testis HSL Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.79 cholesteryl ester + H2O Mus musculus
-
 cholesterol + a carboxylate
-
 ?
3.1.1.79 diacylglycerol + H2O Rattus norvegicus
-
 monoacylglycerol + a carboxylate
-
 ?
3.1.1.79 monoacylglycerol + H2O Rattus norvegicus
-
 glycerol + a carboxylate
-
 ?
3.1.1.79 triacylglycerol + H2O Rattus norvegicus
-
 diacylglycerol + a carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.79 Homo sapiens
-
-
-
3.1.1.79 Mus musculus
-
-
-
3.1.1.79 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.79 phosphoprotein
-
 Homo sapiens
3.1.1.79 phosphoprotein phosphorylation sites at S563 and S565 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.79 adipose tissue
-
 Mus musculus
-
3.1.1.79 adipose tissue
-
 Homo sapiens
-
3.1.1.79 adipose tissue
-
 Rattus norvegicus
-
3.1.1.79 brown adipose tissue
-
 Mus musculus
-
3.1.1.79 testis
-
 Mus musculus
-
3.1.1.79 testis
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.79 100
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.79 1,2-dioleoyl-sn-glycerol + H2O
-
 Homo sapiens 2-oleylglycerol + oleate
-
 ?
3.1.1.79 1,2-dioleoyl-sn-glycerol + H2O
-
 Rattus norvegicus 2-oleylglycerol + oleate
-
 ?
3.1.1.79 cholesteryl ester + H2O
-
 Mus musculus cholesterol + a carboxylate
-
 ?
3.1.1.79 cholesteryl oleate + H2O
-
 Homo sapiens cholesterol + oleate
-
 ?
3.1.1.79 cholesteryl oleate + H2O
-
 Rattus norvegicus cholesterol + oleate
-
 ?
3.1.1.79 diacylglycerol + H2O
-
 Rattus norvegicus monoacylglycerol + a carboxylate
-
 ?
3.1.1.79 monoacylglycerol + H2O
-
 Rattus norvegicus glycerol + a carboxylate
-
 ?
3.1.1.79 p-nitrophenyl butyrate + H2O
-
 Homo sapiens p-nitrophenol + butanoate
-
 ?
3.1.1.79 p-nitrophenyl butyrate + H2O
-
 Rattus norvegicus p-nitrophenol + butanoate
-
 ?
3.1.1.79 triacylglycerol + H2O
-
 Rattus norvegicus diacylglycerol + a carboxylate
-
 ?
3.1.1.79 tributanoylglycerol + H2O
-
 Homo sapiens dibutanoylglycerol + butanoate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.79 ? x * 116000, SDS-PAGE, testis HSL Homo sapiens
3.1.1.79 ? x * 84032, deduced from nucleotide sequence Homo sapiens
3.1.1.79 dimer x * 84073, deduced from nucleotide sequence, HSL might be a homodimer in solution Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
3.1.1.79 HSL
-
 Mus musculus
3.1.1.79 HSL
-
 Homo sapiens
3.1.1.79 HSL
-
 Rattus norvegicus