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Literature summary extracted from

  • Duester, G.; Mic, F.A.; Molotkov, A.
    Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid (2003), Chem. Biol. Interact., 143-144, 201-210.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.36 cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.36 retinal + NAD+ + H2O Mus musculus a null mutation of RALDH2 is embryonic lethal, eliminating most mesodermal synthesis of retinoic acid. Loss of RALDH1 eliminates synthesis od retinoic acid only in the embryonic dorsal retina with no obvious effect on development retinoate + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.36 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.36 retinal + NAD+ + H2O
-
 Mus musculus retinoate + NADH
-
 ?
1.2.1.36 retinal + NAD+ + H2O a null mutation of RALDH2 is embryonic lethal, eliminating most mesodermal synthesis of retinoic acid. Loss of RALDH1 eliminates synthesis od retinoic acid only in the embryonic dorsal retina with no obvious effect on development Mus musculus retinoate + NADH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.36 RALDH
-
 Mus musculus
1.2.1.36 RalDH1
-
 Mus musculus
1.2.1.36 RALDH2
-
 Mus musculus
1.2.1.36 retinaldehyde dehydrogenase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.36 NAD+
-
 Mus musculus