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Literature summary extracted from

  • Zbankova, S.; Bryndova, J.; Kment, M.; Pacha, J.
    Expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in colorectal cancer (2004), Cancer Lett., 210, 95-100.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 cortisol + NAD+ Homo sapiens oxidase that inactivates glucocorticoids to their 11-oxo derivatives cortisone + NADH
-
 ?
1.1.1.146 cortisone + NADPH + H+ Homo sapiens 11betaHSD1 acts as a reductase in vivo cortisol + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Homo sapiens
-
-
-
1.1.1.146 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 adenocarcinoma cell rectum, sigmoid colon Homo sapiens
-
1.1.1.146 adenocarcinoma cell rectum, sigmoid colon Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 cortisol + NAD+ oxidase that inactivates glucocorticoids to their 11-oxo derivatives Homo sapiens cortisone + NADH
-
 ?
1.1.1.146 cortisone + NADPH + H+ 11betaHSD1 acts as a reductase in vivo Homo sapiens cortisol + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 2
-
 Homo sapiens
1.1.1.B40 11betaHSD2
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens
1.1.1.146 11betaHSD1
-
 Homo sapiens