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Literature summary extracted from

  • Wang, Y.; Hacker, A.; Murray-Stewart, T.; Frydman, B.; Valasinas, A.; Fraser, A.V.; Woster, P.M.; Casero Jr, R.A.
    Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity (2005), Cancer Chemother. Pharmacol., 56, 83-90.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.3.13 stable expression of hPAO-1 in A549 cell line Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.3.13 N1,N4-bis(2,3-butadienyl)-1,4-butanediamine i.e. MDL 72,527 Homo sapiens
1.5.3.13 SL-11144 0.01 mM, 80% inhibition Homo sapiens
1.5.3.13 SL-11150 0.01 mM, complete inhibition Homo sapiens
1.5.3.13 SL-11158 0.01 mM, complete inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.3.13 0.00085
-
 N1-acetylspermine pH 8.0 Homo sapiens
1.5.3.13 0.0021
-
 N1-acetylspermidine pH 8.0 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.5.3.13 Homo sapiens Q6QHF9
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.3.13 recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.3.13 (S)-N1-(2-methyl-1-butyl)-N11-ethyl-4,8-diazaundecane-1,11-diamine + O2 + H2O
-
 Homo sapiens ?
-
 ?
1.5.3.13 additional information no efficient hydrolysis of: spermine, spermidine and N8-acetylspermidine, SL-11144, SL-11150, SL-11158 and SL-11156 Homo sapiens ?
-
 ?
1.5.3.13 N1,N12-diacetylspermine + O2 + H2O
-
 Homo sapiens ?
-
 ?
1.5.3.13 N1-acetylspermidine + O2 + H2O
-
 Homo sapiens ?
-
 ?
1.5.3.13 N1-acetylspermine + O2 + H2O
-
 Homo sapiens ?
-
 ?
1.5.3.13 N1-ethyl-N11-(cycloheptyl)methyl-4,8-diazaundecane-1,11-diamine + O2 + H2O
-
 Homo sapiens ?
-
 ?
1.5.3.13 N1-ethyl-N11-(cyclopropyl)methyl-4,8-diazaundecane + O2 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.3.13 hPAO-1
-
 Homo sapiens
1.5.3.13 N1-acetylpolyamine oxidase
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.5.3.13 15
-
 N1-acetylspermidine pH 8.0 Homo sapiens
1.5.3.13 31.7
-
 N1-acetylspermine pH 8.0 Homo sapiens