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Literature summary extracted from

  • Susa, S.; Daimon, M.; Ono, H.; Li, S.; Yoshida, T.; Kato, T.
    Heme inhibits the mitochondrial import of coproporphyrinogen oxidase. Comments (2002), Blood, 100, 4678-4679.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.3.3 in-vitro transcription and translation of the enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.3.3 additional information heme inhibits the mitochondrial import of the enzyme Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.3.3 mitochondrion human enzyme is imported in isolated rat mitochondria, heme inhibits the mitochondrial import of the enzyme completely at 0.02 mM concentration Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2 Homo sapiens enzyme catalyzes the 6th step in heme biosynthesis, heme might be a feed-back regulator of its synthesis by inhibiting the import of th enzyme into mitochondria protoporphyrinogen-IX + CO2 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.3.3 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2
-
 Homo sapiens protoporphyrinogen-IX + CO2 + H2O
-
 ?
1.3.3.3 coproporphyrinogen-III + O2 enzyme catalyzes the 6th step in heme biosynthesis, heme might be a feed-back regulator of its synthesis by inhibiting the import of th enzyme into mitochondria Homo sapiens protoporphyrinogen-IX + CO2 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.3.3 CPO
-
 Homo sapiens