BRENDA - Enzyme Database

alpha-Hydroxyketones as inhibitors of urease

Tanaka, T.; Kawase, M.; Tani, S.; Bioorg. Med. Chem. 12, 501-505 (2004)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.1.5
2,2'-thenoin
IC50: 0.18 mM
Canavalia ensiformis
3.5.1.5
2-hydroxy-1-phenylethanone
IC50: 0.47 mM
Canavalia ensiformis
3.5.1.5
Acetohydroxamic acid
IC50: 0.005 mM
Canavalia ensiformis
3.5.1.5
acetol
IC50: 2.9 mM
Canavalia ensiformis
3.5.1.5
furoin
IC50: 0.36 mM
Canavalia ensiformis
3.5.1.5
Hydroxyurea
IC50: 0.1 mM
Canavalia ensiformis
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.5.1.5
Canavalia ensiformis
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.1.5
urea + H2O
-
654956
Canavalia ensiformis
CO2 + NH3
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3.5.1.5
0.005
-
IC50: 0.005 mM
Canavalia ensiformis
Acetohydroxamic acid
3.5.1.5
0.1
-
IC50: 0.1 mM
Canavalia ensiformis
Hydroxyurea
3.5.1.5
0.18
-
IC50: 0.18 mM
Canavalia ensiformis
2,2'-thenoin
3.5.1.5
0.36
-
IC50: 0.36 mM
Canavalia ensiformis
furoin
3.5.1.5
0.47
-
IC50: 0.47 mM
Canavalia ensiformis
2-hydroxy-1-phenylethanone
3.5.1.5
2.9
-
IC50: 2.9 mM
Canavalia ensiformis
acetol
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3.5.1.5
0.005
-
IC50: 0.005 mM
Canavalia ensiformis
Acetohydroxamic acid
3.5.1.5
0.1
-
IC50: 0.1 mM
Canavalia ensiformis
Hydroxyurea
3.5.1.5
0.18
-
IC50: 0.18 mM
Canavalia ensiformis
2,2'-thenoin
3.5.1.5
0.36
-
IC50: 0.36 mM
Canavalia ensiformis
furoin
3.5.1.5
0.47
-
IC50: 0.47 mM
Canavalia ensiformis
2-hydroxy-1-phenylethanone
3.5.1.5
2.9
-
IC50: 2.9 mM
Canavalia ensiformis
acetol
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.1.5
2,2'-thenoin
IC50: 0.18 mM
Canavalia ensiformis
3.5.1.5
2-hydroxy-1-phenylethanone
IC50: 0.47 mM
Canavalia ensiformis
3.5.1.5
Acetohydroxamic acid
IC50: 0.005 mM
Canavalia ensiformis
3.5.1.5
acetol
IC50: 2.9 mM
Canavalia ensiformis
3.5.1.5
furoin
IC50: 0.36 mM
Canavalia ensiformis
3.5.1.5
Hydroxyurea
IC50: 0.1 mM
Canavalia ensiformis
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.1.5
urea + H2O
-
654956
Canavalia ensiformis
CO2 + NH3
-
-
-
?