EC Number | Application | Comment | Organism |
---|---|---|---|
3.5.3.1 | medicine | enzyme is a target for inhibitors used in therapeutic treatment of smooth muscle disorders, such as erectile dysfunction | Homo sapiens |
3.5.3.1 | pharmacology | enzyme is a target for inhibitor design based on arginine analogues with uncharged, tetrahedral functional groups | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.3.1 | (S)-(2-boronoethyl)-L-cysteine | boronic acid-based transition state analogue, classical competitive inhibition at pH 7.5, slow-binding inhibition at pH 9.5 | Homo sapiens | |
3.5.3.1 | 2(S)-amino-6-boronohexanoic acid | boronic acid-based transition state analogue, classical competitive inhibition at pH 7.5, slow-binding inhibition at pH 9.5 | Homo sapiens | |
3.5.3.1 | agmatine | - |
Homo sapiens | |
3.5.3.1 | L-argininamide | - |
Homo sapiens | |
3.5.3.1 | L-argininic acid | - |
Homo sapiens | |
3.5.3.1 | L-canavanine | - |
Homo sapiens | |
3.5.3.1 | L-homoarginine | - |
Homo sapiens | |
3.5.3.1 | L-N5-(1-iminoethyl)-ornithine | - |
Homo sapiens | |
3.5.3.1 | L-N6-(1-iminoethyl)-lysine | - |
Homo sapiens | |
3.5.3.1 | L-thiocitrulline | - |
Homo sapiens | |
3.5.3.1 | Nomega-amino-L-arginine | - |
Homo sapiens | |
3.5.3.1 | Nomega-hydroxy-L-arginine | competitive, reaction intermediate | Homo sapiens | |
3.5.3.1 | Nomega-hydroxy-nor-L-arginine | competitive, reaction intermediate analogue | Homo sapiens | |
3.5.3.1 | Nomega-Nitro-L-arginine | - |
Homo sapiens | |
3.5.3.1 | S-(2-aminoethyl)isothiourea | - |
Homo sapiens | |
3.5.3.1 | S-(3-aminopropyl)isothiourea | - |
Homo sapiens | |
3.5.3.1 | S-methyl-L-thiocitrulline | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.5.3.1 | mitochondrion | - |
Homo sapiens | 5739 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.3.1 | L-arginine + H2O | Homo sapiens | enzyme is involved in regulation of nitric oxide biosynthesis by modulating arginine availability for nitric oxide synthase | L-ornithine + urea | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.3.1 | Homo sapiens | - |
isozyme type II | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.3.1 | L-arginine + H2O | enzyme is involved in regulation of nitric oxide biosynthesis by modulating arginine availability for nitric oxide synthase | Homo sapiens | L-ornithine + urea | - |
? | |
3.5.3.1 | L-arginine + H2O | reaction intermediate is Nomega-hydroxy-L-arginine | Homo sapiens | L-ornithine + urea | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.3.1 | arginase II | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.5.3.1 | 22 | - |
assay at room temperature | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.3.1 | additional information | - |
additional information | estimated Ki for several inhibitors, overview, inhibition kinetics | Homo sapiens | |
3.5.3.1 | 0.0000085 | - |
2(S)-amino-6-boronohexanoic acid | pH 9.5, 22°C | Homo sapiens | |
3.5.3.1 | 0.00003 | - |
(S)-(2-boronoethyl)-L-cysteine | pH 9.5, 22°C | Homo sapiens | |
3.5.3.1 | 0.000051 | - |
Nomega-hydroxy-nor-L-arginine | pH 7.5, 22°C | Homo sapiens | |
3.5.3.1 | 0.00025 | - |
2(S)-amino-6-boronohexanoic acid | pH 7.5, 22°C | Homo sapiens | |
3.5.3.1 | 0.00031 | - |
(S)-(2-boronoethyl)-L-cysteine | pH 7.5, 22°C | Homo sapiens | |
3.5.3.1 | 0.0016 | - |
Nomega-hydroxy-L-arginine | pH 7.5, 22°C | Homo sapiens |