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Literature summary extracted from
- Hormone-sensitive lipase functions as an oligomer (2000), Biochemistry, 39, 2392-2398.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.1.79 | expression in Sf9 insect cells and COS cells | Rattus norvegicus |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.79 | 0.0022 | - |
cholesteryl oleate | - |
Rattus norvegicus |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.1.79 | cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.79 | 85000 | - |
2 * 85000, immunoblotting, 40fold higher hydrolysis rate for cholesteryl ester than monomer | Rattus norvegicus |
| 3.1.1.79 | 160000 | - |
sucrose density gradient centrifugation | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.79 | cholesteryl oleate + H2O | Rattus norvegicus | - |
cholesterol + oleate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.79 | Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.1.1.79 | phosphoprotein | phosphorylation of HSL appears to be important in enabling dimerization to occur | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.79 | adipose tissue | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.79 | cholesteryl oleate + H2O | - |
Rattus norvegicus | cholesterol + oleate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.1.79 | dimer | 2 * 85000, immunoblotting, 40fold higher hydrolysis rate for cholesteryl ester than monomer | Rattus norvegicus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.79 | HSL | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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