BRENDA - Enzyme Database

Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases

Guranowski, A.; Starzynska, E.; McLennan, A.G.; Baraniak, J.; Stec, W.J.; Biochem. J. 373, 635-640 (2003)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
3.6.1.41
expression of a His-tagged protein in Escherichia coli
Salmonella enterica subsp. enterica serovar Typhimurium
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.17
1,2,3,4-tetra(adenosine-5'-O-phospho)erythritol
-
Homo sapiens
3.6.1.17
1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol
-
Homo sapiens
3.6.1.17
1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol
-
Lupinus angustifolius
3.6.1.17
1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol
-
Homo sapiens
3.6.1.17
1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol
-
Lupinus angustifolius
3.6.1.17
1,3-di(adenosine-5'-O-phospho)-2-phospho-glycerol
-
Homo sapiens
3.6.1.17
1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol
-
Homo sapiens
3.6.1.17
1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol
-
Lupinus angustifolius
3.6.1.17
1,3-di(adenosine-5'-O-phospho)glycerol
-
Homo sapiens
3.6.1.17
1,4-di(adenosine-5'-O-phospho)erythritol
-
Homo sapiens
3.6.1.17
1,4-di(adenosine-5'-O-phospho)erythritol
-
Lupinus angustifolius
3.6.1.17
1,4-di(adenosine-5'-O-phosphorothio)erythritol
-
Homo sapiens
3.6.1.17
1,4-di(adenosine-5'-O-phosphorothio)erythritol
-
Lupinus angustifolius
3.6.1.17
di(adenosine-5'-O-phosphorothio)-di(adenosine-5'-phospho)pentaerythritol
-
Homo sapiens
3.6.1.41
1,2,3,4-tetra(adenosine-5'-O-phospho) erythritol
-
Escherichia coli
3.6.1.41
1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
competitive with respect to Ap4A
Escherichia coli
3.6.1.41
1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
-
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
1,2,3-tri(adenosine-5'-O-phospho) glycerol
-
Escherichia coli
3.6.1.41
1,3-di(adenosine-5'-O-phospho) glycerol
-
Escherichia coli
3.6.1.41
1,3-di(adenosine-5'-O-phospho)-2-phosphoglycerol
-
Escherichia coli
3.6.1.41
1,3-di(adenosine-5'-O-phosphorothio) glycerol
-
Escherichia coli
3.6.1.41
1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
-
Escherichia coli
3.6.1.41
1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
-
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
1,4-di(adenosine-5'-O-phosphorothio) butanediol
-
Escherichia coli
3.6.1.41
1,4-di(adenosine-5'-O-phosphorothio) erythritol
-
Escherichia coli
3.6.1.41
1,5-di(adenosine-5'-O-phosphorothio) pentanediol
-
Escherichia coli
3.6.1.41
di(adenosine-5'-O-phospho)-di(phospho) pentaerythritol
-
Escherichia coli
3.6.1.41
di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
competitive with respect to Ap4A
Escherichia coli
3.6.1.41
di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
-
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
tetra(adenosine-5'-O-phospho) pentaerythritol
-
Escherichia coli
3.6.1.41
tetra(adenosine-5'-O-phosphorothio) pentaerythritol
-
Escherichia coli
3.6.1.41
tetra(adenosine-5'-O-phosphorothio) pentaerythritol
-
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
tri(adenosine-5'-O-phospho)-phospho pentaerythritol
-
Escherichia coli
3.6.1.41
tri(adenosine-5'-O-phosphorothio) glycerol
-
Escherichia coli
3.6.1.41
tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
-
Escherichia coli
3.6.1.41
tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
-
Salmonella enterica subsp. enterica serovar Typhimurium
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.6.1.41
0.005
-
P1,P4-bis(5'-adenosyl) tetraphosphate
pH 7.6, 30C
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
0.025
-
P1,P4-bis(5'-adenosyl) tetraphosphate
pH 7.6, 30C
Escherichia coli
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.6.1.17
Homo sapiens
-
-
-
3.6.1.17
Lupinus angustifolius
-
-
-
3.6.1.41
Escherichia coli
-
K12 strain
-
3.6.1.41
Salmonella enterica subsp. enterica serovar Typhimurium
-
LT2 strain
-
3.6.1.41
Salmonella enterica subsp. enterica serovar Typhimurium LT2
-
LT2 strain
-
Purification (Commentary)
EC Number
Commentary
Organism
3.6.1.41
using Ni-affinity column chromatography to isolate a His-tagged recombinant enzyme
Salmonella enterica subsp. enterica serovar Typhimurium
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.6.1.17
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
-
654523
Homo sapiens
ATP + AMP
-
-
-
?
3.6.1.17
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
-
654523
Lupinus angustifolius
ATP + AMP
-
-
-
?
3.6.1.41
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
654523
Salmonella enterica subsp. enterica serovar Typhimurium
2 ADP
-
-
-
?
3.6.1.41
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
hydrolysis of Ap4A
654523
Escherichia coli
2 ADP
-
-
-
?
3.6.1.41
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
654523
Salmonella enterica subsp. enterica serovar Typhimurium LT2
2 ADP
-
-
-
?
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
3.6.1.17
0.00015
-
1,4-di(adenosine-5'-O-phosphorothio)erythritol
pH 7.6, 30C
Lupinus angustifolius
3.6.1.17
0.0015
-
1,4-di(adenosine-5'-O-phosphorothio)erythritol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.0037
-
di(adenosine-5'-O-phosphorothio)-di(adenosine-5'-phospho)pentaerythritol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.0085
-
1,4-di(adenosine-5'-O-phospho)erythritol
pH 7.6, 30C
Lupinus angustifolius
3.6.1.17
0.013
-
1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol
pH 7.6, 30C
Lupinus angustifolius
3.6.1.17
0.017
-
1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol
pH 7.6, 30C
Lupinus angustifolius
3.6.1.17
0.018
-
1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.025
-
1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol
pH 7.6, 30C
Lupinus angustifolius
3.6.1.17
0.031
-
1,2,3,4-tetra(adenosine-5'-O-phospho)erythritol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.032
-
1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.037
-
1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.066
-
1,3-di(adenosine-5'-O-phospho)-2-phospho-glycerol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.109
-
1,3-di(adenosine-5'-O-phospho)glycerol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.142
-
1,4-di(adenosine-5'-O-phospho)erythritol
pH 7.6, 30C
Homo sapiens
3.6.1.41
0.00002
-
di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
pH 7.6, 30C
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
0.00004
-
di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.00008
-
tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.001
-
di(adenosine-5'-O-phospho)-di(phospho) pentaerythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.0013
-
1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.0014
-
1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.0014
-
tetra(adenosine-5'-O-phosphorothio) pentaerythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.0017
-
tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
pH 7.6, 30C
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
0.0018
-
tetra(adenosine-5'-O-phosphorothio) pentaerythritol
pH 7.6, 30C
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
0.0029
-
1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
pH 7.6, 30C
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
0.003
-
tri(adenosine-5'-O-phospho)-phospho pentaerythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.0039
-
1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
pH 7.6, 30C
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
0.005
-
1,3-di(adenosine-5'-O-phospho)-2-phosphoglycerol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.006
-
1,2,3,4-tetra(adenosine-5'-O-phospho) erythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.007
-
tri(adenosine-5'-O-phosphorothio) glycerol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.028
-
tetra(adenosine-5'-O-phospho) pentaerythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.078
-
1,4-di(adenosine-5'-O-phosphorothio) erythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.089
-
1,4-di(adenosine-5'-O-phosphorothio) butanediol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.109
-
1,5-di(adenosine-5'-O-phosphorothio) pentanediol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.157
-
1,3-di(adenosine-5'-O-phosphorothio) glycerol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.215
-
1,3-di(adenosine-5'-O-phospho) glycerol
pH 7.6, 30C
Escherichia coli
3.6.1.41
4.08
-
1,2,3-tri(adenosine-5'-O-phospho) glycerol
pH 7.6, 30C
Escherichia coli
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.6.1.41
expression of a His-tagged protein in Escherichia coli
Salmonella enterica subsp. enterica serovar Typhimurium
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.17
1,2,3,4-tetra(adenosine-5'-O-phospho)erythritol
-
Homo sapiens
3.6.1.17
1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol
-
Homo sapiens
3.6.1.17
1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol
-
Lupinus angustifolius
3.6.1.17
1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol
-
Homo sapiens
3.6.1.17
1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol
-
Lupinus angustifolius
3.6.1.17
1,3-di(adenosine-5'-O-phospho)-2-phospho-glycerol
-
Homo sapiens
3.6.1.17
1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol
-
Homo sapiens
3.6.1.17
1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol
-
Lupinus angustifolius
3.6.1.17
1,3-di(adenosine-5'-O-phospho)glycerol
-
Homo sapiens
3.6.1.17
1,4-di(adenosine-5'-O-phospho)erythritol
-
Homo sapiens
3.6.1.17
1,4-di(adenosine-5'-O-phospho)erythritol
-
Lupinus angustifolius
3.6.1.17
1,4-di(adenosine-5'-O-phosphorothio)erythritol
-
Homo sapiens
3.6.1.17
1,4-di(adenosine-5'-O-phosphorothio)erythritol
-
Lupinus angustifolius
3.6.1.17
di(adenosine-5'-O-phosphorothio)-di(adenosine-5'-phospho)pentaerythritol
-
Homo sapiens
3.6.1.41
1,2,3,4-tetra(adenosine-5'-O-phospho) erythritol
-
Escherichia coli
3.6.1.41
1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
competitive with respect to Ap4A
Escherichia coli
3.6.1.41
1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
-
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
1,2,3-tri(adenosine-5'-O-phospho) glycerol
-
Escherichia coli
3.6.1.41
1,3-di(adenosine-5'-O-phospho) glycerol
-
Escherichia coli
3.6.1.41
1,3-di(adenosine-5'-O-phospho)-2-phosphoglycerol
-
Escherichia coli
3.6.1.41
1,3-di(adenosine-5'-O-phosphorothio) glycerol
-
Escherichia coli
3.6.1.41
1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
-
Escherichia coli
3.6.1.41
1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
-
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
1,4-di(adenosine-5'-O-phosphorothio) butanediol
-
Escherichia coli
3.6.1.41
1,4-di(adenosine-5'-O-phosphorothio) erythritol
-
Escherichia coli
3.6.1.41
1,5-di(adenosine-5'-O-phosphorothio) pentanediol
-
Escherichia coli
3.6.1.41
di(adenosine-5'-O-phospho)-di(phospho) pentaerythritol
-
Escherichia coli
3.6.1.41
di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
competitive with respect to Ap4A
Escherichia coli
3.6.1.41
di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
-
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
tetra(adenosine-5'-O-phospho) pentaerythritol
-
Escherichia coli
3.6.1.41
tetra(adenosine-5'-O-phosphorothio) pentaerythritol
-
Escherichia coli
3.6.1.41
tetra(adenosine-5'-O-phosphorothio) pentaerythritol
-
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
tri(adenosine-5'-O-phospho)-phospho pentaerythritol
-
Escherichia coli
3.6.1.41
tri(adenosine-5'-O-phosphorothio) glycerol
-
Escherichia coli
3.6.1.41
tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
-
Escherichia coli
3.6.1.41
tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
-
Salmonella enterica subsp. enterica serovar Typhimurium
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
3.6.1.17
0.00015
-
1,4-di(adenosine-5'-O-phosphorothio)erythritol
pH 7.6, 30C
Lupinus angustifolius
3.6.1.17
0.0015
-
1,4-di(adenosine-5'-O-phosphorothio)erythritol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.0037
-
di(adenosine-5'-O-phosphorothio)-di(adenosine-5'-phospho)pentaerythritol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.0085
-
1,4-di(adenosine-5'-O-phospho)erythritol
pH 7.6, 30C
Lupinus angustifolius
3.6.1.17
0.013
-
1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol
pH 7.6, 30C
Lupinus angustifolius
3.6.1.17
0.017
-
1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol
pH 7.6, 30C
Lupinus angustifolius
3.6.1.17
0.018
-
1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.025
-
1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol
pH 7.6, 30C
Lupinus angustifolius
3.6.1.17
0.031
-
1,2,3,4-tetra(adenosine-5'-O-phospho)erythritol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.032
-
1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.037
-
1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.066
-
1,3-di(adenosine-5'-O-phospho)-2-phospho-glycerol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.109
-
1,3-di(adenosine-5'-O-phospho)glycerol
pH 7.6, 30C
Homo sapiens
3.6.1.17
0.142
-
1,4-di(adenosine-5'-O-phospho)erythritol
pH 7.6, 30C
Homo sapiens
3.6.1.41
0.00002
-
di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
pH 7.6, 30C
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
0.00004
-
di(adenosine-5'-O-phosphorothio)-di(phosphorothio) pentaerythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.00008
-
tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.001
-
di(adenosine-5'-O-phospho)-di(phospho) pentaerythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.0013
-
1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.0014
-
1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.0014
-
tetra(adenosine-5'-O-phosphorothio) pentaerythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.0017
-
tri(adenosine-5'-O-phosphorothio)-phosphorothio pentaerythritol
pH 7.6, 30C
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
0.0018
-
tetra(adenosine-5'-O-phosphorothio) pentaerythritol
pH 7.6, 30C
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
0.0029
-
1,2,3,4-tetra(adenosine-5'-O-phosphorothio) erythritol
pH 7.6, 30C
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
0.003
-
tri(adenosine-5'-O-phospho)-phospho pentaerythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.0039
-
1,3-di(adenosine-5'-O-phosphorothio)-2-phosphorothioglycerol
pH 7.6, 30C
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
0.005
-
1,3-di(adenosine-5'-O-phospho)-2-phosphoglycerol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.006
-
1,2,3,4-tetra(adenosine-5'-O-phospho) erythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.007
-
tri(adenosine-5'-O-phosphorothio) glycerol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.028
-
tetra(adenosine-5'-O-phospho) pentaerythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.078
-
1,4-di(adenosine-5'-O-phosphorothio) erythritol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.089
-
1,4-di(adenosine-5'-O-phosphorothio) butanediol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.109
-
1,5-di(adenosine-5'-O-phosphorothio) pentanediol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.157
-
1,3-di(adenosine-5'-O-phosphorothio) glycerol
pH 7.6, 30C
Escherichia coli
3.6.1.41
0.215
-
1,3-di(adenosine-5'-O-phospho) glycerol
pH 7.6, 30C
Escherichia coli
3.6.1.41
4.08
-
1,2,3-tri(adenosine-5'-O-phospho) glycerol
pH 7.6, 30C
Escherichia coli
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.6.1.41
0.005
-
P1,P4-bis(5'-adenosyl) tetraphosphate
pH 7.6, 30C
Salmonella enterica subsp. enterica serovar Typhimurium
3.6.1.41
0.025
-
P1,P4-bis(5'-adenosyl) tetraphosphate
pH 7.6, 30C
Escherichia coli
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.6.1.41
using Ni-affinity column chromatography to isolate a His-tagged recombinant enzyme
Salmonella enterica subsp. enterica serovar Typhimurium
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.6.1.17
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
-
654523
Homo sapiens
ATP + AMP
-
-
-
?
3.6.1.17
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
-
654523
Lupinus angustifolius
ATP + AMP
-
-
-
?
3.6.1.41
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
654523
Salmonella enterica subsp. enterica serovar Typhimurium
2 ADP
-
-
-
?
3.6.1.41
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
hydrolysis of Ap4A
654523
Escherichia coli
2 ADP
-
-
-
?
3.6.1.41
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
654523
Salmonella enterica subsp. enterica serovar Typhimurium LT2
2 ADP
-
-
-
?