Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Visbal, G.; Alvarez, A.; Moreno, B.; San-Blas, G.
    S-adenosyl-L-methionine inhibitors DELTA24-sterol methyltransferase and DELTA24(28)-sterol methylreductase as possible agents against Paracoccidioides brasiliensis (2003), Antimicrob. Agents Chemother., 47, 2966-2970.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.71 20-piperidin-2-yl-5alpha-pregnan-20(R),3beta-diol i.e. AZA-1, inhibits the enzyme and the DELTA24-sterol methyltransferase, leads to accumulation of ergosta-5,7,24(28)-trien-3beta-ol in vivo Paracoccidioides brasiliensis
1.3.1.71 22-piperidin-2-yl-5alpha-pregnan-3beta,22(S)-diol i.e. AZA-2, specific inhibition of the enzyme, leads to accumulatin of ergosta-5,7,22,24(28)-tetraen-3beta-ol in vivo Paracoccidioides brasiliensis
1.3.1.71 22-piperidin-3-yl-5alpha-pregnan-3beta,22(S)-diol i.e. AZA-3, inhibits the enzyme, major proliferative effect and accumulation of lanosterol in vivo Paracoccidioides brasiliensis
1.3.1.71 additional information sterol composition with or without addition of azasterol analogue inhibitors, overview Paracoccidioides brasiliensis
2.1.1.41 22-piperidin-3-yl-pregnan-22(S),3beta-diol
-
 Paracoccidioides brasiliensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.71 ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH Paracoccidioides brasiliensis step in the biosynthesis of ergosta-5,22-dien-3bta-ol, i.e. brassicasterol, the major sterol compound in Paracoccidioides brasiliensis ergosterol + NADP+
-
 ?
1.3.1.71 additional information Paracoccidioides brasiliensis sterol composition with or without addition of azasterol analogue inhibitors, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.71 Paracoccidioides brasiliensis
-
 dimorphic fungus
-
2.1.1.41 Paracoccidioides brasiliensis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.71 additional information organism in its pathogenic yeast-like phase Paracoccidioides brasiliensis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.71 ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH
-
 Paracoccidioides brasiliensis ergosterol + NADP+
-
 ?
1.3.1.71 ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH step in the biosynthesis of ergosta-5,22-dien-3bta-ol, i.e. brassicasterol, the major sterol compound in Paracoccidioides brasiliensis Paracoccidioides brasiliensis ergosterol + NADP+
-
 ?
1.3.1.71 additional information sterol composition with or without addition of azasterol analogue inhibitors, overview Paracoccidioides brasiliensis ?
-
 ?
2.1.1.41 lanosterol + S-adenosyl-L-methionine
-
 Paracoccidioides brasiliensis 24-methylene-24,25-dihydrolanosterol + S-adenosyl-L-homocysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.71 DELTA24(28)-sterol methylreductase
-
 Paracoccidioides brasiliensis
1.3.1.71 SMR
-
 Paracoccidioides brasiliensis
2.1.1.41 DELTA(24,25)-SMT
-
 Paracoccidioides brasiliensis
2.1.1.41 DELTA24-sterol methyltransferase
-
 Paracoccidioides brasiliensis

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.71 NADPH
-
 Paracoccidioides brasiliensis