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Literature summary extracted from
- Cancer procoagulant activity studies using synthetic peptidyl substrates (1997), Thromb. Res., 87, 251-256.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.22.26 | medicine | enzyme has potential as a sensitive and early tumor marker | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.26 | iodoacetamide | - |
Homo sapiens |  |
| 3.4.22.26 | trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane | ie.e. E-64 | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.22.26 | 0.027 | - |
D-Ile-Pro-Arg-4-nitroanilide | pH 7.2 | Homo sapiens | |
| 3.4.22.26 | 0.061 | - |
N-p-tosyl-Gly-Pro-Arg-4-nitroanilide | pH 7.2 | Homo sapiens | |
| 3.4.22.26 | 0.109 | - |
D-Ala-Pro-Arg-4-nitroanilide | pH 7.2 | Homo sapiens | |
| 3.4.22.26 | 0.153 | - |
N-p-tosyl-Gly-Pro-Lys-4-nitroanilide | pH 7.2 | Homo sapiens | |
| 3.4.22.26 | 0.306 | - |
Glu-Glu-Pro-Arg-4-nitroanilide | pH 7.2 | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.26 | factor X + H2O | Homo sapiens | cleavage of Arg-Ile bond, activation of the coaglutation factor X | factor Xa | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.22.26 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.22.26 | to homogeneity | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.22.26 | amnion | - |
Homo sapiens | - |
| 3.4.22.26 | chorion | - |
Homo sapiens | - |
| 3.4.22.26 | additional information | produced by malignant and fetal cells | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.22.26 | additional information | - |
- |
Homo sapiens |
| 3.4.22.26 | 47 | - |
purified enzyme | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.26 | benzyloxycarbonyl-Arg-Arg-4-nitroanilide + H2O | - |
Homo sapiens | benzyloxycarbonyl-Arg-Arg + 4-nitroaniline | - |
? | |
| 3.4.22.26 | benzyloxycarbonyl-Leu-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | benzyloxycarbonyl-Leu-Pro-Arg + 4-nitroaniline | - |
? | |
| 3.4.22.26 | benzyloxycarbonyl-Val-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | benzyloxycarbonyl-Val-Pro-Arg + 4-nitroaniline | - |
? | |
| 3.4.22.26 | D-Ala-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | D-Ala-Pro-Arg + 4-nitroaniline | - |
? | |
| 3.4.22.26 | D-Ile-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | D-Ile-Pro-Arg + 4-nitroaniline | - |
? | |
| 3.4.22.26 | D-Phe-Pip-Arg-4-nitroanilide + H2O | - |
Homo sapiens | D-Phe-Pip-Arg + 4-nitroaniline | - |
? | |
| 3.4.22.26 | factor X + H2O | cleavage of Arg-Ile bond | Homo sapiens | factor Xa | - |
? | |
| 3.4.22.26 | factor X + H2O | cleavage of Arg-Ile bond, activation of the coaglutation factor X | Homo sapiens | factor Xa | - |
? | |
| 3.4.22.26 | Fibrinogen + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.22.26 | Glu-Glu-Phe-Lys-4-nitroanilide + H2O | - |
Homo sapiens | Glu-Glu-Phe-Lys + 4-nitroaniline | - |
? | |
| 3.4.22.26 | Glu-Glu-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | Glu-Glu-Pro-Arg + 4-nitroaniline | - |
? | |
| 3.4.22.26 | Leu-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | Leu-Pro-Arg + 4-nitroaniline | - |
? | |
| 3.4.22.26 | methylsulfonyl-D-cyclohexylalanyl-butyl-Arg-4-nitroanilide + H2O | - |
Homo sapiens | methylsulfonyl-D-cyclohexylalanyl-butyl-Arg + 4-nitroaniline | - |
? | |
| 3.4.22.26 | additional information | substrate specificity, overview | Homo sapiens | ? | - |
? | |
| 3.4.22.26 | N-p-tosyl-Gly-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | N-p-tosyl-Gly-Pro-Arg + 4-nitroaniline | - |
? | |
| 3.4.22.26 | N-p-tosyl-Gly-Pro-Lys-4-nitroanilide + H2O | - |
Homo sapiens | N-p-tosyl-Gly-Pro-Lys + 4-nitroaniline | - |
? | |
| 3.4.22.26 | sarcosyl-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | sarcosyl-Pro-Arg + 4-nitroaniline | - |
? | |
| 3.4.22.26 | Val-Pro-Arg-4-nitroanilide + H2O | - |
Homo sapiens | Val-Pro-Arg + 4-nitroaniline | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.22.26 | cancer procoagulant | - |
Homo sapiens |
| 3.4.22.26 | CP | - |
Homo sapiens |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.22.26 | 0.0073 | - |
N-p-tosyl-Gly-Pro-Arg-4-nitroanilide | pH 7.2 | Homo sapiens | |
| 3.4.22.26 | 0.0082 | - |
D-Ile-Pro-Arg-4-nitroanilide | pH 7.2 | Homo sapiens | |
| 3.4.22.26 | 0.0119 | - |
Glu-Glu-Pro-Arg-4-nitroanilide | pH 7.2 | Homo sapiens | |
| 3.4.22.26 | 0.0129 | - |
N-p-tosyl-Gly-Pro-Lys-4-nitroanilide | pH 7.2 | Homo sapiens | |
| 3.4.22.26 | 0.0132 | - |
D-Ala-Pro-Arg-4-nitroanilide | pH 7.2 | Homo sapiens | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.22.26 | 7.2 | - |
assay at | Homo sapiens |
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