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Literature summary extracted from

  • Kutzler, M.A.; Solter, P.F.; Hoffman, W.E.; Volkmann, D.H.
    Characterization and localization of alkaline phosphatase in canine seminal plasma and gonadal tissues (2003), Theriogenology, 60, 299-306.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.1 diagnostics the enzyme is a useful marker of the sperm-rich fraction of the ejaculate Canis lupus familiaris

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.1 levamisole complete inhibition of the seminal plasma enzyme at 4.2 mM Canis lupus familiaris

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.1 Canis lupus familiaris
-
 beagle and mixed breed, 2 genes encoding 2 isozyme types: a tissue non-specific isozyme and an intestinal isozyme
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.1 glycoprotein sialic acid containing carbohydrates, different pattern for the different isozymes Canis lupus familiaris

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.3.1 a phosphate monoester + H2O = an alcohol + phosphate Wide specificity. Also catalyses transphosphorylations. Some enzymes hydrolyse diphosphate Canis lupus familiaris
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.1 blood contains liver and bone isozymes Canis lupus familiaris
-
3.1.3.1 bone bone isozyme is of the non-specific type Canis lupus familiaris
-
3.1.3.1 epididymis fluid, high activity, secretion of the enzyme, localized to caput, corpora, and cauda Canis lupus familiaris
-
3.1.3.1 epithelium epididymal and seminiferous tubular epithelium, seminal plasma isozyme is of the non-specific type, secretion of the enzyme, no activity in the basal membrane of the epididymal epithelial cells Canis lupus familiaris
-
3.1.3.1 intestine intestinal isozyme type Canis lupus familiaris
-
3.1.3.1 liver liver isozyme is of the non-specific type Canis lupus familiaris
-
3.1.3.1 additional information tissue distribution, 2 isozyme types: a tissue non-specific isozyme and an intestinal isozyme type, different forms of these isozymes are bone, liver, seminal plasma and kidney enzymes of the non-specific type, and intestine and corticosteroid-inducible enzymes of the intestinal type Canis lupus familiaris
-
3.1.3.1 osteosarcoma cell bone isozyme is of the non-specific type Canis lupus familiaris
-
3.1.3.1 prostate low activity Canis lupus familiaris
-
3.1.3.1 seminal plasma seminal plasma specific isozyme of the non-specific type Canis lupus familiaris
-
3.1.3.1 serum
-
 Canis lupus familiaris
-
3.1.3.1 sperm
-
 Canis lupus familiaris
-
3.1.3.1 testis low activity, localized on the surface of the seminiferous epithelial cells and tubules Canis lupus familiaris
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.1 additional information
-
 activity in different tissue and fluid samples Canis lupus familiaris

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.1 5-bromo-4-chloro-3-indolyl phosphate + nitroblue tetrazolium i.e. BCIP/NBT system Canis lupus familiaris ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.1 alkaline phosphatase
-
 Canis lupus familiaris
3.1.3.1 AP
-
 Canis lupus familiaris
3.1.3.1 SAP
-
 Canis lupus familiaris
3.1.3.1 seminal plasma alkaline phosphatase
-
 Canis lupus familiaris
3.1.3.1 seminal plasma AP
-
 Canis lupus familiaris