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Literature summary extracted from

  • Irazusta, J.; Larrinaga, G.; Agirregoitia, N.; Varona, A.; Casis, L.
    Effects of morphine administration and its withdrawal on rat brain aminopeptidase activities (2003), Regul. Pept., 110, 225-230.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.11.2 morphine increase in activity in the striatum by 28% compared to untreated rats, and slightly in the hypothalamus and amygdala, withdrawal of the opioid reduces enzyme activity by 42%, overview Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 additional information the enzyme is puromycin-insensitive Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.2 membrane bound Rattus norvegicus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Rattus norvegicus
-
 male Sprague-Dawley
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 amygdala
-
 Rattus norvegicus
-
3.4.11.2 brain
-
 Rattus norvegicus
-
3.4.11.2 hippocampus
-
 Rattus norvegicus
-
3.4.11.2 hypothalamus
-
 Rattus norvegicus
-
3.4.11.2 striatum
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.11.2 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 Ala-beta-naphthylamide + H2O
-
 Rattus norvegicus Ala + beta-naphthylamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.2 aminopeptidase N
-
 Rattus norvegicus
3.4.11.2 APN
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.11.2 37
-
 assay at Rattus norvegicus