EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
4.1.1.22 | D53N/D54N | crystal structure of apo-D53N/D54N double mutant and of mutant complexed with the substrate-analog inhibitor histidine methyl ester, crystals are grown at room temperature by hanging-drop vapor diffusion, drops contain 0.005 ml HDC at 12 mg/ml and 0.005 ml of precipitant solution from the well containing 0-15% polyethylene glycol 400, 4-8% polyethylene glycol 4000, 100 mM sodium acetate, pH 4.6, crystals diffract to 3.2 A | Lactobacillus sp. |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.22 | L-histidine | Lactobacillus sp. | - |
histamine + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.1.22 | Lactobacillus sp. | - |
30a | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.22 | L-histidine | - |
Lactobacillus sp. | histamine + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.1.22 | HDC | - |
Lactobacillus sp. |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.1.1.22 | 4.8 | - |
HDC is essentially inactive at neutral and alkaline pH and active at low pH, low pH shifts HDC from the inactive, i.e. T-state, to the active, i.e. R-state | Lactobacillus sp. |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.22 | additional information | HDC uses a covalently bound pyruvoyl moiety as cofactor | Lactobacillus sp. |