Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hetman, J.M.; Robas, N.; Baxendale, R.; Fidock, M.; Phillips, S.C.; Soderling, S.H.; Beavo, J.A.
    Cloning and characterization of two splice variants of human phosphodiesterase 11A (2000), Proc. Natl. Acad. Sci. USA, 97, 12891-12895.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 dipyridamole 50% inhibition at 0.00082 mM; 50% inhibition at 0.0018 mM Homo sapiens
3.1.4.17 zaprinast 50% inhibition at 0.005 mM; 50% inhibition at 0.028 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.17 0.0033
-
 cAMP pH 7.5 Homo sapiens
3.1.4.17 0.0037
-
 cGMP pH 7.5 Homo sapiens
3.1.4.17 0.0042
-
 cGMP pH 7.5 Homo sapiens
3.1.4.17 0.0057
-
 cAMP pH 7.5 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.17 65800
-
 x * 65800, deduced from gene sequence Homo sapiens
3.1.4.17 78100
-
 x * 78100, deduced from gene sequence Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Homo sapiens Q9HCR9 isozyme PDE11A2
-
3.1.4.17 Homo sapiens Q9HCR9 isozyme PDE11A3
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 cAMP + H2O
-
 Homo sapiens AMP
-
 ?
3.1.4.17 cGMP + H2O
-
 Homo sapiens GMP
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.17 ? x * 65800, deduced from gene sequence Homo sapiens
3.1.4.17 ? x * 78100, deduced from gene sequence Homo sapiens