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Literature summary extracted from

  • Ruiz-Stewart, I.; Tiyyagura, S.R.; Lin, J.E.; Kazerounian, S.; Pitari, G.M.; Schulz, S.; Martin, E.; Murad, F.; Waldman, S.A.
    Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism (2004), Proc. Natl. Acad. Sci. USA, 101, 37-42.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 NO
-
 Homo sapiens
4.6.1.2 sodium nitroprusside NO donor Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.2 expression of sGC in insect cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.2 8-aza-3ATP inhibition of basal and sodium nitroprusside activated sGC activity Homo sapiens
4.6.1.2 ATP allosteric inhibition of basal and sodium nitroprusside activated sGC activity Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.6.1.2 0.16
-
 GTP 37°C, pH 7.5, in the absence of ATP Homo sapiens
4.6.1.2 0.36
-
 GTP 37°C, pH 7.5, in the presence of 1 mM ATP Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Homo sapiens
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 vascular smooth muscle cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 sGC
-
 Homo sapiens
4.6.1.2 soluble guanylyl cyclase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.6.1.2 2.3
-
 ATP 37°C, pH 7.5 Homo sapiens